DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_444414.2	Gene:	Ugt2a1 / 94215	MGIID:	2149905	Length:	528	Species:	Mus musculus

Alignment Length:	559	Identity:	158/559 - (28%)
Similarity:	273/559 - (48%)	Gaps:	64/559 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQL 69
            :|..:||.....|.|.::.|..:| ::...| ||::....:|.||:...|.||::.|       .
Mouse     1 MLKNILLCSLQISLLGMSLGGNVL-IWPMEG-SHWLNVKIIIDELLRKEHNVTVLVA-------S 56

  Fly    70 GSNY-TEILIEPVYDFWHDVKLNFGAQHL------FELTRMTN-----------YDFLKMLE--- 113
            |:.: |...|.|...| ....:.||.:.:      |.||.:.|           .:..|::|
Mouse    57 GALFITPSSISPSLTF-EIYPVPFGKEKIESVIKDFVLTWLENRPSPSTIWTFYKEMAKVIEEFH 120

  Fly   114 IIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQ-----EAFLALAHLYKIPVVTTSTLG 173
            ::.....:..|:..|:.|.:..|:    |::||::..:.     ...|.:..:|.:.....||:
Mouse   121 LVSRGICDGVLKNEKLMSKLQKEK----FEVLLSDPVFPCGDIVALKLGIPFIYSLRFSPASTV- 180

  Fly   174 YENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNY-----FPKMDAVA 233
             |.|..::.   .|.|:||......||:|||.:||:| :.|:     |:.:|     :.:.|:..
Mouse   181 -EKHCGKVP---FPPSYVPAILSELTDQMSFTDRVRN-FISY-----RMQDYMFETLWKQWDSYY 235

  Fly   234 REFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLD 298
            .:..|...|....:...|    :.|:.::......||.:.....|||:|..|.||||.:|:..:.
Mouse   236 TKALGRPTTLCETMGKAE----IWLMRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQ 296

  Fly   299 GATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQA 362
            .:.| |.:.|||||.|  |::..|...|.......:.|:|||:::.:....|..|..:..|:||.
Mouse   297 TSGEHGIVVFSLGSMV--KNLTDEKANLIASALAQIPQKVLWRYKGKIPDTLGSNTRLFDWIPQN 359

  Fly   363 DILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEIL 427
            |:|.|...:.||||||..|..|.:::.:||:|:|.:.||..|:......|.|:.::..::|...|
Mouse   360 DLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSSDL 424

  Fly   428 RHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYL 492
            .::|..:|:..:||||..|:|.|..|:|::|...||:|||:|:||:||.|:|.|..||:|||::.
Mouse   425 LNALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHS 489

  Fly   493 LDVIAF-VAIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            ||||.| :|.:|.|.::.....:.:.....|..:|.|::
Mouse   490 LDVIGFLLACVASAILLVAKCCLFIFQKVGKTGKKKKRD 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	148/514 (29%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	143/492 (29%)
Ugt2a1	NP_444414.2	UDPGT	21..516	CDD:278624	149/525 (28%)
Ugt2a1	NP_444414.2	egt	<267..487	CDD:223071	83/221 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840275
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690