DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	158/519 - (30%)
Similarity:	269/519 - (51%)	Gaps:	51/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHFMMHTALIRELVESGHQVTMV----TAFSLEKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHL 97
            ||:|....::.|||:.||:||::    :.|...||   ::..:.:..|.....||:: ||..:.:
  Rat    34 SHWMNIKIILEELVQKGHEVTVLRPSASVFLDPKE---TSDLKFVTFPTSFSSHDLE-NFFTRFV 94

  Fly    98 ----FELTRMT--NYDFLKMLEIIG------LKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQF 150
                :||.|.|  :| ||.:.:.|.      |...:.|:...:..:.:    :|..||::.::..
  Rat    95 NVWTYELPRDTCLSY-FLYLQDTIDEYSDYCLTVCKEAVSNKQFMTKL----QESKFDVVFSDAI 154

  Fly   151 YQEAFLALAHLYKIPVVTTSTL--GY--ENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNS 211
            .....| :|.|.:||.:.:...  ||  |.::.   |::.|.|:||..|.....:|:|:|||.|.
  Rat   155 GPCGEL-IAELLQIPFLYSLRFSPGYTIEKYIG---GVLFPPSYVPMIFSGLAGQMTFIERVHNM 215

  Fly   212 YASFYEDMDRLLNYF-----PKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPT 271
            ....|.|.     :|     .|.|    .|:...|.....:..:..:..:.|:.|:..|....|.
  Rat   216 ICMLYFDF-----WFQTFREKKWD----PFYSKTLGRPTTLAEIMGKAEMWLIRSYWDLEFPHPI 271

  Fly   272 VDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ 335
            ...:..:||:|..|.||||.|::..:..:.| |.:.|||||.|  ::|..|...:.......:.|
  Rat   272 SPNVDYIGGLHCKPAKPLPKDIEDFVQSSGEHGVVVFSLGSMV--RNMTEEKANIIAWALAQIPQ 334

  Fly   336 RVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCD 400
            :|||:|:.:....|..|..:.|||||.|:|.|...|.|:||||..|..|.:|:.:||:|||.:.:
  Rat   335 KVLWRFDGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVTHGGANGIYEAIHHGIPMIGIPLFGE 399

  Fly   401 QHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYW 465
            ||.|:...|..|.|:.::|:::::..:.::|:::|:|..||:|...:|.|..|:|.:|...||:|
  Rat   400 QHDNIAHMVAKGAAVEVNFRTMSKSDMLNALEEVINNPFYKKNAMWLSTIHHDQPTKPLDRAVFW 464

  Fly   466 IEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAF-VAIIALAGVMALSLAIRLLMGSNKKHRKAK 528
            ||:|:||:||.|:||.|.:|.|:|::.||||.| :..:|:..|:||...:.:.....||.:|.|
  Rat   465 IEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIGFLLTCVAVTVVLALKCFLFVYRFFVKKEKKTK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	150/493 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	149/486 (31%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	156/516 (30%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	83/220 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344212
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690