DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and UGT2A3

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_011530549.1	Gene:	UGT2A3 / 79799	HGNCID:	28528	Length:	533	Species:	Homo sapiens

Alignment Length:	545	Identity:	163/545 - (29%)
Similarity:	258/545 - (47%)	Gaps:	86/545 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 FPGK--------SHFMMHTALIRELVESGHQVTMVT-------------AFSLEKEQLGSNYT-- 74
            |.||        ||::....::.||:..||:||::|             |...|...:..:.|
Human    22 FCGKVLVWPCDMSHWLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKPSALKFEVVHMPQDRTEE 86

  Fly    75 -EILIE------PVYDFWHDV-KLNFGAQHLFELTRMTNYDFLKMLEIIG---LKTTEHALRQPK 128
             ||.::      |....|..| |||               ||  .:||.|   :........|..
Human    87 NEIFVDLALNVLPGLSTWQSVIKLN---------------DF--FVEIRGTLKMMCESFIYNQTL 134

  Fly   129 VRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMG-LITPWSFVP 192
            ::.|     :|..:|::|.:.......| :|.|..:|.|.|..:....:|.:..| |..|.|:||
Human   135 MKKL-----QETNYDVMLIDPVIPCGDL-MAELLAVPFVLTLRISVGGNMERSCGKLPAPLSYVP 193

  Fly   193 HGFMPFTDRMSFLERVKNSYAS-----FYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMER 252
            ......||||:||||||||..|     :.:|.|  .:::       .||:...|.....:.....
Human   194 VPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYD--YHFW-------EEFYSKALGRPTTLCETVG 249

  Fly   253 QISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLP------ADMQALLDGATE-GAIFFSLG 310
            :..:.|:.::......:|.......|||:|..|.|.||      .:|:..:..:.| |.:.||||
Human   250 KAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALPKINFYLQEMENFVQSSGEDGIVVFSLG 314

  Fly   311 SNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFIT 375
            |..|  ::..|...:.......:.|:|||:::.:..|.|..|..:..|:||.|:|.|...|.|||
Human   315 SLFQ--NVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFIT 377

  Fly   376 HGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTY 440
            |||:.|..|.:::.|||:|:|.:.||..|:......|.|:.::|:::|.|.|..:|..:|.:.:|
Human   378 HGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSY 442

  Fly   441 KENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAF-VAIIAL 504
            |||..|:|.|..|:|::|...||:|||:|:||:||.|:|||..||.|||.|.:|||.| :|.:|
Human   443 KENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFLLACVA- 506

  Fly   505 AGVMALSLAIRLLMGSNKKHRKAKQ 529
               .|:.|..:..:.|.:|..|.::
Human   507 ---TAIFLFTKCFLFSCQKFNKTRK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	157/518 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	152/499 (30%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	162/541 (30%)
UGT2A3	XP_011530549.1	egt	<267..498	CDD:223071	88/232 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150251
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690