DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt5b4

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001074161.1	Gene:	ugt5b4 / 791210	ZFINID:	ZDB-GENE-070112-2332	Length:	531	Species:	Danio rerio

Alignment Length:	529	Identity:	138/529 - (26%)
Similarity:	269/529 - (50%)	Gaps:	43/529 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQFPLLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMV-TAFSL 64
            |.:|:...|||.     ...:.|...:| |:...| ||::....|:..|...||.:|:: .:.|.
Zfish     8 MLWPVTLCLLLV-----MAPVVESGNVL-VFPVDG-SHWVNMNILVEALHAKGHNITVIRMSDSW 65

  Fly    65 EKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKM-LEI----IGLKTTEHAL 124
            ..::...:||.|.::....|..|:...|.::.:..|...:.:..||: :|:    :.:..||..:
Zfish    66 YIKEFSPHYTSITLKSSGGFSEDILETFASRLITILRDGSTWGRLKLEMEMWQSSLKIMETEREM 130

  Fly   125 RQPKVRSLIHAEQ-----KEGVFDLLLAEQFYQEAFLALAHLYKIPVVTT---STLGYENHMSQM 181
                :.::|..:|     |:..:||.|.:.......: |.:..|:|:|..   :..| |.|.
Zfish   131 ----IINMIEDQQLIDSLKKTKYDLFLTDPAMYGGVI-LGNYLKLPIVYNVRWAIFG-EGHF--- 186

  Fly   182 MGLI--TPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEV 244
              :|  :|.|:||...:...|||||||||||.......:........|..:.:...|.||.:
Zfish   187 --VIAPSPLSYVPVAMLELPDRMSFLERVKNVVMYIITETQIAFLIAPTYNVLCERFIGPGV--- 246

  Fly   245 PKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFS 308
             .:.::.:...:.|..:.......|||:..:|.:.|....|.||||.|::..:..:.: |.|..|
Zfish   247 -NLFNLVQGADLWLHRADFVFEYPRPTMPNIVYMAGFQCKPSKPLPKDLEDFVQSSGDHGVIVMS 310

  Fly   309 LGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVF 373
            ||:.:  ..:|.::.....:.|..|.|:::|:::.:..|.|.:|.::..|:||.|:|.|...:.|
Zfish   311 LGTII--GQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLIMDWMPQNDLLGHPKTRAF 373

  Fly   374 ITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNV 438
            :.|||..|.||.:::.||::|.....||..|::|..:.|.|.::.|.::.:|....::.:::::.
Zfish   374 VAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTVKEVLYDP 438

  Fly   439 TYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIA 503
            :|:||:||:|.:.:|.|::|..:|::|||:|:||:||:|:|:....:.|:.::.:|||  :.:|:
Zfish   439 SYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVI--LVLIS 501

  Fly   504 LAGVMALSL 512
            ...::.||:
Zfish   502 AVSLIILSI 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	131/498 (26%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	126/477 (26%)
ugt5b4	NP_001074161.1	egt	12..501	CDD:223071	133/514 (26%)
ugt5b4	NP_001074161.1	UDPGT	27..531	CDD:278624	132/505 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585208
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790