DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	580	Identity:	152/580 - (26%)
Similarity:	259/580 - (44%)	Gaps:	111/580 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLLLTGTLYSQLELAEGSKILAVYAFPGK-SHFMMHTALIRELVESGHQVTMVTAFS------LE 65
            |.||...|...:::....::|.:   ||: ||:.....:|..||:..|.||::...|      .:
Zfish     4 GALLVCLLLCGVDVGWSGRVLVM---PGEYSHWHNMRPVIEALVDKNHSVTVLVGSSSPTVPHTQ 65

  Fly    66 KEQLGSNYTEILIEPVYDFWHDVKLNFGAQ----------HLFELTRMTNYD------------- 107
            ||:..              :|..|:|...:          |||.......|:
Zfish    66 KERFE--------------YHVFKVNMEKEEADAAMRDMIHLFTNDTAAKYEGEFVMWKVMSKFV 116

  Fly   108 -----FLKMLEIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVV 167
                 :.:.|..:||..|                .::..:|:|.::.....:.| :|....||.|
Zfish   117 EFGDVYFRGLFDVGLLKT----------------LRDSNYDVLFSDPMMPFSDL-MAQKLNIPQV 164

  Fly   168 TT--STLGY--ENHMSQMMGLITPWSFVP------HGFMPFTDRMSFLERVKNSYASFYEDMDRL 222
            .:  :|..|  |....||.   .|.|:||      |    .||||||:|||:|           :
Zfish   165 ISMRATFAYAAERLCGQMP---APPSYVPAVALTDH----LTDRMSFMERVEN-----------M 211

  Fly   223 LNY------FPKMDAVARE-FFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGG 280
            |.|      ||.:.....: ::..:|.:...:.....::.:.|:.::......||.......|||
Zfish   212 LLYIVHSIAFPLVATFTFDGYYSEILGKPTTMCETMGKVDICLIRTYWDFEYPRPFPPNFKFVGG 276

  Fly   281 MHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDE 344
            :|..|.|||..:::..:..:.: |.:.|||||.:  |::..|.........|.:.|:|:|::..:
Zfish   277 LHCKPAKPLSKELEEFVQSSGDHGVVVFSLGSMI--KNLTSERANTIAAALGQIPQKVVWRYSGK 339

  Fly   345 SISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAV 409
            :...|..|..:..|:||.|:|.|...|.||||||..|..|.:::.|||:|:|.:.||..|:....
Zfish   340 TPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLLHIK 404

  Fly   410 LGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRG 474
            ..|.|:.|...::..:.|..:|..:::|.:|||::.|:|.|..|:|::|...||||||:|:|::|
Zfish   405 TKGAAVVLDIHTMGSKDLVDALKAVVNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKG 469

  Fly   475 ASHMRSAGLDLNWFQFYLLDVIAFV----AIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            |.|:|....:|:|:|::.|||.||:    |:|....|.|.....|..:...:..||.::|
Zfish   470 AKHLRVQAHELSWYQYHCLDVAAFLLSITALITFLWVKACCFLFRRCVRKTRPERKRQKN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	142/538 (26%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	135/512 (26%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	145/551 (26%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	77/237 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585274
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690