DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt5c2

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001038851.1	Gene:	ugt5c2 / 751669	ZFINID:	ZDB-GENE-060825-206	Length:	552	Species:	Danio rerio

Alignment Length:	518	Identity:	146/518 - (28%)
Similarity:	262/518 - (50%)	Gaps:	43/518 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIEPVYDFW 85
            |.:|.||| |....| ||::....||:.|...||.|.::...:....:..|.|.:.:..|....|
Zfish    45 LCDGGKIL-VAPLEG-SHWVNMDILIKALHGQGHTVDVIRNANSWFIKENSTYYDTITIPNTKGW 107

  Fly    86 HDVKLNFGAQHLFELTRMTNYDFLK--MLEIIGL--------KTTEHALRQPKVRSLIHAEQ--- 137
            .:   .|.|..::   :|..|:..|  .|.|:.|        |.| |.:....:.:::.:|:
Zfish   108 DE---EFAADFVY---KMIKYEKEKGSWLSIVRLYLNVFDAVKKT-HEMVCQLITNILDSEEILK 165

  Fly   138 --KEGVFDLLLAEQFYQEAFLALAHLYKIPVVTT---STLGYENHMSQMMGLITPWSFVPHGFMP 197
              .|..:||:|.:..:....: |||..|:|:|..   :|.| |.|.....   :|.|::|.....
Zfish   166 MLNEKQYDLMLTDPVWGTGII-LAHKLKLPMVYNVRWTTTG-EGHFDIAP---SPMSYIPITGSG 225

  Fly   198 FTDRMSFLERVKNSYASFYEDMDRLLNYF--PKMDAVAREFFGPVLTEVPKVKHMERQISVMLLN 260
            .||||||.:|:||.:  ||..:|..|::|  .:..|:..::|    |.......:.:...:.|:.
Zfish   226 NTDRMSFFQRLKNYF--FYLLLDLQLSHFNVKQYQAICDKYF----TSRVNFHELLQGADLWLMR 284

  Fly   261 SHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLR 324
            ........|||:..::.:||....|.||||.|::..:..:.: |.|..||||.:  .::|..:..
Zfish   285 VDFVFEFPRPTMPNIIYIGGFQCPPAKPLPHDLEDFMQSSGDHGVIVMSLGSLI--GNLPENVTA 347

  Fly   325 LFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYA 389
            .....|..|.|:|:|::..:..|.|.:|.::..|:||.|:|.|...||||:|||..|..|.:::.
Zfish   348 EIAAAFARLPQKVIWRYTGKKPSTLSNNTLMVDWMPQKDLLGHPKTKVFISHGGTNGVLEALYHG 412

  Fly   390 VPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDR 454
            ||::||||:.||:.|:.:....|.|..|....:.|..|..::.::|:..:|:.|:.::|.:.:|:
Zfish   413 VPVIGIPFFFDQYDNLIRLQARGGAKLLSIADLGENTLHAAIQEVINEPSYRLNMHKLSHLHKDK 477

  Fly   455 PLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGVMALSLAIRLL 517
            |::|..||::|||:|:||:||:|:|:....:.|:.::.:||:..:..:.|.....:.:.:|.|
Zfish   478 PVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVVVTLFAVVLILTYCIFVTVRYL 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	142/502 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	136/481 (28%)
ugt5c2	NP_001038851.1	UDPGT	49..551	CDD:278624	144/514 (28%)
ugt5c2	NP_001038851.1	egt	<288..528	CDD:223071	77/241 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585283
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690