Protein Alignment Ugt49C1 and UGT2B10

DIOPT Version :10

• Sequence 1: NP_611564.2
• Gene: Ugt49C1 / 37421
• FlyBaseID: FBgn0034605
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 162/570 - (28%)
• Similarity: 267/570 - (46%)
• Gaps: 98/570 - (17%)

  Fly    12 TGTLYSQLE--LAEGS--KIL---AVYAFPGKSHFMMHTALIRELVESGHQVTMVT--------- 60
            |..|..||.  .:.||  |:|   |.|     |.:|....:::|||:.||:||::.
Human     6 TTVLLIQLSFYFSSGSCGKVLVWAAEY-----SLWMNMKTILKELVQRGHEVTVLASSASILFDP 65

  Fly    61 --AFSLEKEQLGSNYTEILIEPVY-------------DFW-------------HDVKLNFGAQHL 97
              :.:|:.|...::.|:...|.:.             .||             :|:..||...
Human    66 NDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAINDIIRNFCKD-- 128

  Fly    98 FELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLY 162
                .::|...:|.|:                         |..||::.|:.:.....| ||.|:
Human   129 ----VVSNKKLMKKLQ-------------------------ESRFDIVFADAYLPCGEL-LAELF 163

  Fly   163 KIPVVTTSTL--GY--ENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNS-YASFYEDMDRL 222
            .||.|.:.:.  ||  |.|..   |.|.|.|:||......:|:|:|:|||||. |..:::...::
Human   164 NIPFVYSHSFSPGYSFERHSG---GFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQI 225

  Fly   223 LNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPK 287
            .| ..|.|    :|:..||.....:....|:..:.|:.:........|.:..:..|||:|..|.|
Human   226 FN-MKKWD----QFYSEVLGRPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAK 285

  Fly   288 PLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPD 351
            |||.:|:..:..:.| |.:.|||||.|  .:|..|...:.......:.|:|||:|:......|..
Human   286 PLPKEMEEFVQSSGENGVVVFSLGSMV--SNMTEERANVIATALAKIPQKVLWRFDGNKPDALGL 348

  Fly   352 NVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAIS 416
            |..:.||:||.|:|.|...:.||||||..|..|.:::.:||:|||.:.||..|:......|.|:.
Human   349 NTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVR 413

  Fly   417 LHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSA 481
            :.|.:::...|.::|..:|::.:||||:.::|.|..|:|::|...||:|||:|:||:||.|:|.|
Human   414 VDFNTMSSTDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA 478

  Fly   482 GLDLNWFQFYLLDVIAF-VAIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            ..:|.|||::.||||.| :|.:|....:.....:.......:|.:|.|::
Human   479 AHNLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_611564.2	Glycosyltransferase_GTB-type	37..498	CDD:471961	146/503 (29%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	154/547 (28%)