DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and UGT2B4

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_066962.2	Gene:	UGT2B4 / 7363	HGNCID:	12553	Length:	528	Species:	Homo sapiens

Alignment Length:	489	Identity:	149/489 - (30%)
Similarity:	246/489 - (50%)	Gaps:	51/489 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHFMMHTALIRELVESGHQVTMVTA---------------FSLEKEQLGSNYTEILIEPVYDFWH 86
            ||:|....::.|||:.||:||::.:               |.:....|.....|.:|:.:...|
Human    34 SHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRW- 97

  Fly    87 DVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIHAEQ-----KEGVFDLLL 146
                       .||.:.|.:.:...::.| :.|....||: ..:.::..::     :|..||::|
Human    98 -----------AELPKDTFWSYFSQVQEI-MWTFNDILRK-FCKDIVSNKKLMKKLQESRFDVVL 149

  Fly   147 AEQFYQEAFLALAHLYKIPVVTTSTL--GY--ENHMSQMMGLITPWSFVPHGFMPFTDRMSFLER 207
            |:..:....| ||.|.|||.|.:...  ||  |.|..   ||:.|.|:||......:|:|:|:||
Human   150 ADAVFPFGEL-LAELLKIPFVYSLRFSPGYAIEKHSG---GLLFPPSYVPVVMSELSDQMTFIER 210

  Fly   208 VKNS-YASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPT 271
            |||. |..::|...::.: ..|.|    :|:..||.....:.....:..:.|:.::.......|.
Human   211 VKNMIYVLYFEFWFQIFD-MKKWD----QFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPL 270

  Fly   272 VDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ 335
            :..:..|||:|..|.||||.:|:..:..:.| |.:.|||||.|.:..  .|...:.......:.|
Human   271 LPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNTS--EERANVIASALAKIPQ 333

  Fly   336 RVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCD 400
            :|||:|:......|..|..:.||:||.|:|.|...:.||||||..|..|.:::.:||:|:|.:.|
Human   334 KVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFAD 398

  Fly   401 QHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYW 465
            |..|:......|.|:||.|.:::...|.::|..:|::..||||..::|.|..|:|::|...||:|
Human   399 QPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFW 463

  Fly   466 IEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFV 499
            ||:|:||:||.|:|.|..||.|||::.|||..|:
Human   464 IEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	149/489 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	148/486 (30%)
UGT2B4	NP_066962.2	egt	8..512	CDD:223071	149/489 (30%)
UGT2B4	NP_066962.2	UDPGT	24..524	CDD:278624	149/489 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150710
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690