DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_082370.2	Gene:	Ugt2a3 / 72094	MGIID:	1919344	Length:	534	Species:	Mus musculus

Alignment Length:	557	Identity:	166/557 - (29%)
Similarity:	258/557 - (46%)	Gaps:	100/557 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SKILAVYAFP-GKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIE-----PVYD 83
            ||:|   .:| ..||::....::.||...||:||::            .|..|:|:     |::
Mouse    24 SKVL---VWPCDMSHWLNLKTILEELGARGHEVTVL------------KYPSIIIDQSKRIPLH- 72

  Fly    84 FWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIHAE--------QKEG 140
             :.::.|      |:|:....|    ::.||..|     |:......||..|.        |..|
Mouse    73 -FENIPL------LYEIETAEN----RLNEIANL-----AVNVIPNLSLWEAAKTLQDFFLQVTG 121

  Fly   141 VFDLLLAEQFYQEAFL---------------------ALAHLYKIPVVTT--STLGY--ENHMSQ 180
            .|:.:.....|.:.|:                     .:|.:.:||.|.|  .::||  |.|..|
Mouse   122 DFESICRSVLYNQKFMDKLRDAQYDVVVIDPVVPCGELVAEVLQIPFVYTLRFSMGYYMEKHCGQ 186

  Fly   181 MMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNY------FPKMDAVAREFFGP 239
               |..|.|:||......||.|:|.|||||...|.      |..|      |...|....|..|.
Mouse   187 ---LPIPLSYVPVVMSELTDNMTFTERVKNMMFSL------LFEYWLQQYDFAFWDQFYSETLGR 242

  Fly   240 VLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-G 303
            ..|....|    .:..:.|:.::..:...||.:.....|||:|..|.||||.:|:..:..:.| |
Mouse   243 PTTFCKTV----GKADIWLIRTYWDVEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQSSGEHG 303

  Fly   304 AIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHR 368
            .:.|||||.|  |::..|...|...|...:.|:|||::..:..:.|..|..:..|:||.|:|.|.
Mouse   304 VVVFSLGSMV--KNLTEEKANLIASVLAQIPQKVLWRYSGKKPATLGSNTRLFNWIPQNDLLGHP 366

  Fly   369 HVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQ 433
            ..|.||||||..|..|.:::.|||:|:|...||..|:......|.|:.:...::|...|..::..
Mouse   367 KTKAFITHGGTNGIYEAIYHGVPMVGVPMLGDQPHNIAHMEAKGAALKVSISTMTSTDLLSAVRA 431

  Fly   434 LIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAF 498
            :|:..:||||..|:|.|..|:|::|...||:|||:|:||:||.|:|.|..||:|||::.||||.|
Mouse   432 VINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGF 496

  Fly   499 --VAIIALAGVM---ALSLAIRLLMGSNKK--HRKAK 528
              :.::.|..::   .|.:..:|.|..:||  :||.|
Mouse   497 LLLCVVTLTFIITKFCLFVCQKLYMKESKKMGNRKKK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	157/526 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	152/505 (30%)
Ugt2a3	NP_082370.2	UDPGT	25..526	CDD:278624	160/547 (29%)
Ugt2a3	NP_082370.2	egt	<268..507	CDD:223071	92/240 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840302
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690