DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_038948318.1	Gene:	Ugt2a1 / 63867	RGDID:	69432	Length:	528	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	157/572 - (27%)
Similarity:	268/572 - (46%)	Gaps:	98/572 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGK-SHFMMHTALIRELVESGHQVTMVTAFS----- 63
            |:|.|.||..:.|      |:.::    :|.. ||::....|:.|||:..|.||::.|..
  Rat     9 LIFPLALTEIVLS------GNVVI----WPSDGSHWLNIKILLEELVQRNHSVTVLAASETLFIN 63

  Fly    64 ------LEKEQLGSNYT----EILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKML------ 112
                  :..|::..:||    :.:||.:...|.|          ...|.:|.:.|.|.|
  Rat    64 SSPDAFISFEEIPVSYTRSKIDEMIEHMIALWLD----------HRPTPLTMWAFYKELGKLFAA 118

  Fly   113 -EIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQF--------------------YQEAFL 156
             ..|..:..:..|:    .:.:.|..::|.||:|:::..                    :..||.
  Rat   119 FYKINKQICDGVLK----NATLMARLQKGGFDVLISDPVTMCGELVALKLGIPFVYTLRFSPAFT 179

  Fly   157 ALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDR 221
            ...|..|||                    ||.|:||......||:|:|.|||||:.:  |...|.
  Rat   180 VERHCGKIP--------------------TPVSYVPAALSELTDQMTFGERVKNTIS--YSLQDY 222

  Fly   222 LL-NYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYP 285
            :. :|:.:.::    ::..||.....:.....:..:.|:.::......||.:.....|||:|..|
  Rat   223 IFKSYWGEWNS----YYSRVLGRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHCKP 283

  Fly   286 PKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQL 349
            .||||.:|:..:..:.| |.:.|||||.|  |::..|...|.......:.|:|||:::.:..:.|
  Rat   284 AKPLPKEMEEFVQTSGEHGVVVFSLGSMV--KNLTEEKANLIASALAQIPQKVLWRYKGKIPATL 346

  Fly   350 PDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYA 414
            ..|..:..|:||.|:|.|...:.||||||..|..|.:::.:||:|:|.:.||..|:......|.|
  Rat   347 GSNTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAA 411

  Fly   415 ISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMR 479
            :.::..::|...|..::..:|:...||||..|:|.|..|:|::|...||:|||:|:||:||.|:|
  Rat   412 VEVNMNTMTSADLLSAVRAVINEPFYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLR 476

  Fly   480 SAGLDLNWFQFYLLDVIAF-VAIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            .|..||:|||::.||||.| :|.:|.|.::.:...:.:.....|..:|.|::
  Rat   477 VAAHDLSWFQYHSLDVIGFLLACMASAILLVIKCCLFVFQKIGKTGKKNKRD 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	146/527 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	142/504 (28%)
Ugt2a1	XP_038948318.1	UDPGT	22..524	CDD:278624	149/547 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860