DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	165/572 - (28%)
Similarity:	272/572 - (47%)	Gaps:	101/572 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTA--------- 61
            |.||||  .||: |..|||.|:| |:...| ||::....::|||...|||..::..
  Rat    10 LAGLLL--LLYA-LPWAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEE 69

  Fly    62 --FSLE-----------KEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLE 113
              |:|:           ::|:..|     |:.|::..:.||           |.:...:.||.:.
  Rat    70 DFFTLQTYPVPYTRQGFRQQMMRN-----IKVVFETGNYVK-----------TFLETSEILKNIS 118

  Fly   114 IIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVV---TTSTLGYE 175
            .:.|::..:.|....:...:::..    ||::|.:... .....||....||.|   .....|.:
  Rat   119 TVLLRSCMNLLHNGSLLQHLNSSS----FDMVLTDPVI-PCGAVLAKYLGIPTVFFLRYIPCGID 178

  Fly   176 NHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKN-------SYASFYEDMDRLLNYFPKMDAVA 233
            :..:|..   .|.|::|:.....:|.|:||:||||       .|...:.        |.:.:::|
  Rat   179 SEATQCP---KPSSYIPNLLTMLSDHMTFLQRVKNMLYPLALKYICHFS--------FTRYESLA 232

  Fly   234 REFFGPVLTEVPKVKHMERQISVMLLNSHAPL---------TTARPTVDAMVPVGGMHIYPPKPL 289
            .|.             ::|::|::.:.|||.:         ...||.:..||.:||::....|||
  Rat   233 SEL-------------LQREVSLVEVLSHASVWLFRGDFVFDYPRPVMPNMVFIGGINCVIKKPL 284

  Fly   290 PADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNV 353
            ..:.:|.::.:.| |.:.|||||.|  .::|.:......:..|.:.|.|||::.....|.|..|.
  Rat   285 SQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNT 347

  Fly   354 MVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLH 418
            ::.|||||.|:|.|...:.||||.|..|..||:...|||:.:|.:.||..|..:....|..::|:
  Rat   348 ILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLN 412

  Fly   419 FQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGL 483
            ...:|.:.|.::|..:|:|.:||||:.|:|.:.:|||:||...||:|:|||:||:||.|:|.|..
  Rat   413 VLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAH 477

  Fly   484 DLNWFQFYLLDVIAFVAIIALAGVM----ALSLAIRLLMGSN---KKHRKAK 528
            ||.|:|::.||||.|:..|.|..|.    :.:...|...|..   ||..|:|
  Rat   478 DLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	149/523 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	140/502 (28%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	150/544 (28%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	93/247 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344206
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790