DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt5g1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001107914.1	Gene:	ugt5g1 / 570913	ZFINID:	ZDB-GENE-080305-10	Length:	528	Species:	Danio rerio

Alignment Length:	560	Identity:	146/560 - (26%)
Similarity:	255/560 - (45%)	Gaps:	93/560 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LYSQLELAEGSKILAVYAFP-GKSHFMMHTALIRELVESGHQVTMV------------------T 60
            |.|.:....|..||   .|| ..||::....::|:|...||..|:|                  |
Zfish    14 LLSVVCCCHGGNIL---VFPEDGSHWVNMQVILRKLHTHGHSFTVVRSSKSWYIHENSALYNTIT 75

  Fly    61 AFSLEKEQLGSNYTEILIE---------PVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIG 116
            ...:|.|.:|.:|..:|::         |:..|:...|         ::|.:.......:|.::.
Zfish    76 VNPVETEDVGQDYFNMLLDRSLALQKMSPLVRFFEQQK---------DITTVLKVFHNGVLRMVS 131

  Fly   117 LKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGY------- 174
            ....:..|    |:||     :|..|||||.:..:....| :|:..::|:|      |
Zfish   132 AMLDDAEL----VKSL-----REAKFDLLLTDPAFPAGVL-VANFLQLPMV------YNVRWLNA 180

  Fly   175 -ENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFG 238
             :.||....   :|.|:||.......|:||||:||:|    |...:..||.        .|....
Zfish   181 GDAHMQTAP---SPPSYVPMYNSLLHDQMSFLQRVEN----FLRYLCSLLQ--------ERYVIV 230

  Fly   239 PVLTEVPKVKH---------MERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQ 294
            |:..|:.: :|         |::...:.|:.........|||:..::.:||....|.:.||.|::
Zfish   231 PIYRELLE-RHFPPGSDLLSMQQSADIWLMRMDFVFDFPRPTMPNIIYMGGFQCKPAQALPVDLE 294

  Fly   295 ALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKW 358
            ..:..:.| |.:|.|||:.|.:  :|..:.......|..:.|:|:|::..|..|.|.:|.::.:|
Zfish   295 EFMQSSGEHGVVFMSLGAMVGA--LPRTITEAIASAFAKIPQKVMWRYHGERPSTLGNNTLLLEW 357

  Fly   359 LPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSIT 423
            .||.|:|.|...:.|::|||..|..|.:::.||:|.:|...||..|:.:..:...|..|...::|
Zfish   358 FPQNDLLGHPKTRAFVSHGGTNGIYEAIYHGVPVLALPLLFDQFDNVMRLQVRNAARVLQVATLT 422

  Fly   424 EEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWF 488
            .:.....|..::.|..|:.:::::|::.||:|:.|..||.:|||||:||:||:|:||...:|.|:
Zfish   423 SQEFLEGLKDVLENPLYRSSIRKMSELHRDQPISPLDSATFWIEYVMRHKGAAHLRSEANNLAWY 487

  Fly   489 QFYLLDVIAFVAIIALAGVMALSLAIRLLMGSNKKHRKAK 528
            .::.|||:.|:..||:..........|.|. ..|..:|.|
Zfish   488 SYHSLDVLVFLLAIAVIAFWTSVYVCRFLC-CRKSIKKRK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	138/527 (26%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	131/505 (26%)
ugt5g1	NP_001107914.1	UDPGT	24..526	CDD:278624	142/548 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585223
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790