DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	544	Identity:	147/544 - (27%)
Similarity:	261/544 - (47%)	Gaps:	80/544 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMV----TAFSLEK 66
            |||.           |.:|.|||.| ...| ||::....||:.|...||.:.::    :.:..||
Zfish    20 LFGF-----------LCDGGKILVV-PLEG-SHWLNMDILIKALHGKGHSIDVIRNTNSWYVKEK 71

  Fly    67 EQ------------LGSNYTEILIEPVYDF------W-HDVKLNFGAQHLFELTRMTNYDFLKML 112
            ..            :...:.:.:|..|.:.      | ..|||.|.:.       :.||:..||:
Zfish    72 SDYYNSITIPQSKGMDEEFVDDMISKVINHERGKSSWLSTVKLFFDSV-------IDNYEMTKMV 129

  Fly   113 EIIGLKTTEHALRQPKVRSLIHAEQ-----KEGVFDLLLAEQFYQEAFLALAHLYKIPVV----- 167
            ..|   ||          |:..:|:     :|..:||:|.:..:....: |||..|:|:|
Zfish   130 CDI---TT----------SIFESEEILKTLQEKQYDLMLTDPVWGMGII-LAHKLKLPMVYNVRW 180

  Fly   168 TTSTLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAV 232
            ||:..|:.|...      :|.|::|......||||||.:||||....|..|:.......|:..|:
Zfish   181 TTTVDGHFNIAP------SPMSYIPITGSGNTDRMSFFQRVKNIIFYFTNDIKYSRFSLPQYQAI 239

  Fly   233 AREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALL 297
            ..::|.|.:    ....:.:...:.|:.........|||:..::..||....|.||||.|::..:
Zfish   240 CDKYFDPPV----DFYQLLQGADIWLMRVDFVFEFPRPTMPNIIYTGGFQCTPAKPLPHDLEDFM 300

  Fly   298 DGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQ 361
            ..:.: |.|..|||:.:.:  :|.::.......|..|.|:|:|::..:..|.|.:|.::..|:||
Zfish   301 QSSGDHGVIVMSLGTFISA--LPEDVTAEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQ 363

  Fly   362 ADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEI 426
            .|:|.|...|||:.|||..|.||.:::.||::||||:.||:.|:.:....|.|..:....:.|..
Zfish   364 KDLLGHPKTKVFVAHGGTNGVQEALYHGVPVVGIPFFFDQYDNLIRLQARGGAKIVSLAELGENS 428

  Fly   427 LRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFY 491
            |..::.::|:|.:|:..:|::|.:..|:|::|..||::|||:|:||:||:|:|:....:.|:.::
Zfish   429 LHAAIKEVINNPSYRLTMQKLSQLHLDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYH 493

  Fly   492 LLDVIAFVAIIALAGVMALSLAIR 515
            .:||...:..:.|..:.::...:|
Zfish   494 SVDVAVTLIAVVLIFIFSIFYVVR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	141/515 (27%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	135/494 (27%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	142/525 (27%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	76/241 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585284
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690