DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt8

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	543	Identity:	144/543 - (26%)
Similarity:	242/543 - (44%)	Gaps:	68/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIEP----- 80
            |:..:||:.|.....:||..:...|...|...||....:.  |..:|...||:..:...|
Zfish    18 LSWAAKIVVVPPIMFESHLYIFKTLASALHAEGHDTVFLV--SEGREIPPSNHYRLQRYPGIFNS 80

  Fly    81 --VYDFWHDVKLNFGAQHLF--ELTRMTNYDFLKMLE-----IIGLKTTEHALRQPKVRSLIHAE 136
              ..||     |....:::|  .||.:..:|.|....     ::|..:....|::..
Zfish    81 TSADDF-----LQSKVRNIFSGRLTALELFDILDHYSQNCDAVVGSTSVMEQLKREH-------- 132

  Fly   137 QKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTST-LGYENHMSQMMGLITPWSFVPHGFMPFTD 200
                 |||||.:......|: :||:..:.....|| |.|...    :|...|.|:||......||
Zfish   133 -----FDLLLVDPNEMCGFV-IAHILGVQYAVFSTGLWYPAE----VGAPAPLSYVPEFNSLLTD 187

  Fly   201 RMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREF-FGPVLTEVPKVKHMERQISVMLLNSHAP 264
            .||..:||.|:...............||.|.:.|:: ..|.::    :..:.:...:.:|.:...
Zfish   188 HMSLFQRVANTAVYLVSRFGVQFLVLPKYDRIMRKYNIQPSVS----MHDLVQNSRLWMLCTDMA 248

  Fly   265 LTTARPTVDAMVPVGGMHIYPPKPLPADMQA-LLDGATEGAIFFSLGSNVQSKDMPVEMLRLFLQ 328
            |...|||:..:|.|||:...||.|||.:.:. :.|...:|.:..|.|:.|  |.:..::.:....
Zfish   249 LEFPRPTLPHVVYVGGILTKPPSPLPQEFETWVKDTDEDGFVVVSFGAGV--KYLSDDIAQKLAG 311

  Fly   329 VFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPML 393
            ....|.|||:|:|.....|.|.:|..:..|:||.|:|...:.:.|::||||....|.:::.||::
Zfish   312 ALSRLPQRVIWRFSGVPPSNLGNNTKLVDWMPQNDLLGQTNTRAFLSHGGLNSIYEAMYHGVPVV 376

  Fly   394 GIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEP 458
            |:|.:.|.:..|.:....|..|.|.::.::||.|..::..:|.:..|:|..|.:|.|.:|:|..|
Zfish   377 GVPLFGDHYDTMTRVQAKGMGIMLEWKRMSEEDLYTAMVNVITDKRYRERAQLLSQIHKDQPGHP 441

  Fly   459 RKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAI-IALAGV----MALSLAIRLLM 518
            ...|||||.|::|||||.|:|||..::..:|::||||...:.: :.|.|.    :...:..||..
Zfish   442 VSRAVYWISYILRHRGAEHLRSAVYEIPTYQYFLLDVAMVIGVCLLLTGYCLYRIVKFIQFRLGR 506

  Fly   519 GS---------------NKKHRK 526
            ||               |.||::
Zfish   507 GSSPGEKVNGHCHNGIPNGKHKR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	134/499 (27%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	131/477 (27%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	136/508 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585292
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.740