DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt2a2

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001019319.1	Gene:	Ugt2a2 / 552899	MGIID:	3576095	Length:	528	Species:	Mus musculus

Alignment Length:	570	Identity:	162/570 - (28%)
Similarity:	264/570 - (46%)	Gaps:	104/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LYSQLELAE----GSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVT------------AFS 63
            |...|.|||    |:  :.|:...| ||::....|:.|||:..|.||::.            ||
Mouse     9 LIFHLTLAEIVLSGN--VVVWPTDG-SHWLNIKILLEELVQRNHSVTVLAPSETLFINSRLDAF- 69

  Fly    64 LEKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFEL------TRMTNYDFLKMLEIIGLKTT-- 120
            :..|::..:||:..|:.:            .:|:..|      |.:|.:.|.|  |:..|..|
Mouse    70 INFEEIPVSYTKSKIDEI------------IEHMIALWLDHRPTPLTMWTFYK--ELGNLLATFY 120

  Fly   121 -------EHALRQPKVRSLIHAEQKEGVFDLLLAEQF--------------------YQEAFLAL 158
                   :..|..|.|...:    ::|.||:|||:..                    :..||...
Mouse   121 TTNKQMCDGVLNNPTVMERL----QKGGFDVLLADPVTMCGELVALKLGIPFVYTLRFSPAFTVE 181

  Fly   159 AHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLL 223
            .|..|||                    .|.|:||......||:|||.|||||..:  |...|.:.
Mouse   182 RHCGKIP--------------------APISYVPAALSELTDQMSFGERVKNIIS--YSLQDYIF 224

  Fly   224 -NYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPK 287
             .|:.:.::    ::..||.....:.....:..:.|:.::......||.:.....|||:|..|.|
Mouse   225 KTYWGEWNS----YYSKVLGRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHCKPAK 285

  Fly   288 PLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPD 351
            |||.:|:..:..:.| |.:.|||||.|  |::..|...|.......:.|:|||:::.:....|..
Mouse   286 PLPKEMEEFVQTSGEHGIVVFSLGSMV--KNLTDEKANLIASALAQIPQKVLWRYKGKIPDTLGS 348

  Fly   352 NVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAIS 416
            |..:..|:||.|:|.|...:.||||||..|..|.:::.:||:|:|.:.||..|:......|.|:.
Mouse   349 NTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVE 413

  Fly   417 LHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSA 481
            ::..::|...|.::|..:|:..:||||..|:|.|..|:|::|...||:|||:|:||:||.|:|.|
Mouse   414 VNMNTMTSSDLLNALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA 478

  Fly   482 GLDLNWFQFYLLDVIAF-VAIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            ..||:|||::.||||.| :|.:|.|.::.....:.:.....|..:|.|::
Mouse   479 AHDLSWFQYHSLDVIGFLLACVASAILLVAKCCLFIFQKVGKTGKKKKRD 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	154/535 (29%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	147/509 (29%)
Ugt2a2	NP_001019319.1	UDPGT	22..516	CDD:278624	154/543 (28%)
Ugt2a2	NP_001019319.1	egt	<267..487	CDD:223071	83/221 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840269
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790