Protein Alignment Ugt49C1 and UGT1A3

DIOPT Version :9

• Sequence 1: NP_001036565.1
• Gene: Ugt49C1 / 37421
• FlyBaseID: FBgn0034605
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 158/576 - (27%)
• Similarity: 264/576 - (45%)
• Gaps: 95/576 - (16%)

  Fly     1 MQFPLLF---GLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAF 62
            :|.||.:   ||||   |.|....||..|:|.| ...| ||::....::|||...|||..::|.
Human     5 LQVPLPWLATGLLL---LLSVQPWAESGKVLVV-PIDG-SHWLSMREVLRELHARGHQAVVLTP- 63

  Fly    63 SLEKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELT----RMTNYDFLKMLEIIG----LKT 119
                                    :|.::...::.|.||    ..|..:|.:  .::|    ...
Human    64 ------------------------EVNMHIKEENFFTLTTYAISWTQDEFDR--HVLGHTQLYFE 102

  Fly   120 TEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGY-ENHMSQMMG 183
            |||.|:: ..||:........|:.....|..:.||.:...:.....||.|..:.. ...:::.:.
Human   103 TEHFLKK-FFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLS 166

  Fly   184 LIT--------------------PWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPK 228
            :.|                    |.|::|......:|.|:|::||||            :.|...
Human   167 IPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKN------------MLYPLA 219

  Fly   229 MDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAP---------LTTARPTVDAMVPVGGMHIY 284
            :..:...|..|..:...::  .:|::||:.:.|||.         :...||.:..||.:||::..
Human   220 LSYICHAFSAPYASLASEL--FQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCA 282

  Fly   285 PPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQ 348
            ..|||..:.:|.::.:.| |.:.|||||.|  .::|.:.........|.:.|.|||::.....|.
Human   283 NRKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSN 345

  Fly   349 LPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGY 413
            |.:|.::.|||||.|:|.|...:.||||.|..|..|.:...|||:.:|.:.||..|..:....|.
Human   346 LANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGA 410

  Fly   414 AISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHM 478
            .::|:...:|.|.|.::|..:|::.:||||:.|:|.:.:|||:||...||:|:|:|:||:||.|:
Human   411 GVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHL 475

  Fly   479 RSAGLDLNWFQFYLLDVIAF----VAIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            |.|..||.|:|::.||||.|    |..:|.......:...|..:|...:.:||.::
Human   476 RPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKS 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	144/524 (27%)
		UDPGT	37..498	CDD:278624	136/499 (27%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	145/541 (27%)
		egt	<262..508	CDD:223071	90/247 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150729
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790