DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and UGT1A1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_000454.1	Gene:	UGT1A1 / 54658	HGNCID:	12530	Length:	533	Species:	Homo sapiens

Alignment Length:	551	Identity:	165/551 - (29%)
Similarity:	270/551 - (49%)	Gaps:	54/551 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PLLFGLLL--TGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEK 66
            ||:.||||  .|.:.|     ...|||.:..  ..||::.....|::|.:.||::.::...:...
Human    10 PLVLGLLLCVLGPVVS-----HAGKILLIPV--DGSHWLSMLGAIQQLQQRGHEIVVLAPDASLY 67

  Fly    67 EQLGSNYTEILIEPVYDFWHDVKLNFGA--QHLFELTRMTNYDFLKMLEIIGLKT-----TEHAL 124
            .:.|:.|| :...||.....|||.:|.:  .::||     |..||:.:    :||     .:.|:
Human    68 IRDGAFYT-LKTYPVPFQREDVKESFVSLGHNVFE-----NDSFLQRV----IKTYKKIKKDSAM 122

  Fly   125 RQPKVRSLIH-----AEQKEGVFDLLLAEQFYQ-----EAFLALAHLYKIPVVTTSTLGYENHMS 179
            .......|:|     |...|..||::|.:.|..     ..:|:|..::.:..:..| |.:|....
Human   123 LLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCS-LEFEATQC 186

  Fly   180 QMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEV 244
            .     .|:|:||......:|.|:||:||||...:|.::....:.|.| ...:|.||....:|
Human   187 P-----NPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSP-YATLASEFLQREVT-- 243

  Fly   245 PKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFS 308
              |:.:....||.|..|.......||.:..||.|||::.....||..:.:|.::.:.| |.:.||
Human   244 --VQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFS 306

  Fly   309 LGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVF 373
            |||.|  .::|.:.........|.:.|.|||::.....|.|.:|.::.|||||.|:|.|...:.|
Human   307 LGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAF 369

  Fly   374 ITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNV 438
            |||.|..|..|.:...|||:.:|.:.||..|..:....|..::|:...:|.|.|.::|..:|::.
Human   370 ITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDK 434

  Fly   439 TYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAF----V 499
            :||||:.|:|.:.:|||:||...||:|:|:|:||:||.|:|.|..||.|:|::.||||.|    |
Human   435 SYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV 499

  Fly   500 AIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            ..:|.......:...|..:|...:.:||.::
Human   500 LTVAFITFKCCAYGYRKCLGKKGRVKKAHKS 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	152/503 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	147/478 (31%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	155/520 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150692
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8488
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.720