Protein Alignment Ugt49C1 and UGT1A4

DIOPT Version :10

• Sequence 1: NP_611564.2
• Gene: Ugt49C1 / 37421
• FlyBaseID: FBgn0034605
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 158/581 - (27%)
• Similarity: 252/581 - (43%)
• Gaps: 105/581 - (18%)

  Fly     1 MQFP---LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAF 62
            :|.|   |..||||   |.|....||..|:|.| ...|.....|..|| |||...|||..::|.
Human     5 LQVPLPRLATGLLL---LLSVQPWAESGKVLVV-PTDGSPWLSMREAL-RELHARGHQAVVLTP- 63

  Fly    63 SLEKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELT------RMTNYDFLKMLEIIGLKTTE 121
                                    :|.::...:..|.||      ....:|.:.:....|...||
Human    64 ------------------------EVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETE 104

  Fly   122 HALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLI- 185
            |.|::.. ||:...............|..:.||.:...:.....||.|..:       .:.|.:
Human   105 HLLKRYS-RSMAIMNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPV-------NLCGAVL 161

  Fly   186 ---------------------------TPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLL 223
                                       .|.|::|......:|.|:||:||||            :
Human   162 AKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKN------------M 214

  Fly   224 NYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAP---------LTTARPTVDAMVPVG 279
            .|...:..:...|..|..:...::  .:|::||:.|.|:|.         :...||.:..||.:|
Human   215 LYPLALSYICHTFSAPYASLASEL--FQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIG 277

  Fly   280 GMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFED 343
            |::....|||..:.:|.::.:.| |.:.|||||.|  .::|.:.........|.:.|.|||::..
Human   278 GINCANGKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG 340

  Fly   344 ESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKA 408
            ...|.|.:|.::.|||||.|:|.|...:.||||.|..|..|.:...|||:.:|.:.||..|..:.
Human   341 TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRM 405

  Fly   409 VLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHR 473
            ...|..::|:...:|.|.|.::|..:|::.:||||:.|:|.:.:|||:||...||:|:|:|:||:
Human   406 ETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHK 470

  Fly   474 GASHMRSAGLDLNWFQFYLLDVIAF----VAIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            ||.|:|.|..||.|:|::.||||.|    |..:|.......:...|..:|...:.:||.::
Human   471 GAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKS 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_611564.2	Glycosyltransferase_GTB-type	37..498	CDD:471961	136/504 (27%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	145/546 (27%)