DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and UGT1A4

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_009051.1	Gene:	UGT1A4 / 54657	HGNCID:	12536	Length:	534	Species:	Homo sapiens

Alignment Length:	581	Identity:	158/581 - (27%)
Similarity:	252/581 - (43%)	Gaps:	105/581 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQFP---LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAF 62
            :|.|   |..||||   |.|....||..|:|.| ...|.....|..|| |||...|||..::|.
Human     5 LQVPLPRLATGLLL---LLSVQPWAESGKVLVV-PTDGSPWLSMREAL-RELHARGHQAVVLTP- 63

  Fly    63 SLEKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELT------RMTNYDFLKMLEIIGLKTTE 121
                                    :|.::...:..|.||      ....:|.:.:....|...||
Human    64 ------------------------EVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETE 104

  Fly   122 HALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLI- 185
            |.|::.. ||:...............|..:.||.:...:.....||.|..:       .:.|.:
Human   105 HLLKRYS-RSMAIMNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPV-------NLCGAVL 161

  Fly   186 ---------------------------TPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLL 223
                                       .|.|::|......:|.|:||:||||            :
Human   162 AKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKN------------M 214

  Fly   224 NYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAP---------LTTARPTVDAMVPVG 279
            .|...:..:...|..|..:...::  .:|::||:.|.|:|.         :...||.:..||.:|
Human   215 LYPLALSYICHTFSAPYASLASEL--FQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIG 277

  Fly   280 GMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFED 343
            |::....|||..:.:|.::.:.| |.:.|||||.|  .::|.:.........|.:.|.|||::..
Human   278 GINCANGKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG 340

  Fly   344 ESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKA 408
            ...|.|.:|.::.|||||.|:|.|...:.||||.|..|..|.:...|||:.:|.:.||..|..:.
Human   341 TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRM 405

  Fly   409 VLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHR 473
            ...|..::|:...:|.|.|.::|..:|::.:||||:.|:|.:.:|||:||...||:|:|:|:||:
Human   406 ETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHK 470

  Fly   474 GASHMRSAGLDLNWFQFYLLDVIAF----VAIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            ||.|:|.|..||.|:|::.||||.|    |..:|.......:...|..:|...:.:||.::
Human   471 GAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKS 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	144/529 (27%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	136/504 (27%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	145/546 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150728
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690