Protein Alignment Ugt49C1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_001036565.1
• Gene: Ugt49C1 / 37421
• FlyBaseID: FBgn0034605
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 170/583 - (29%)
• Similarity: 261/583 - (44%)
• Gaps: 109/583 - (18%)

  Fly     1 MQFP---LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAF 62
            :|.|   |..||||   |.|....||..|:|.|..  ..||::.....:|:|...||||.::|
Human     5 LQVPLPQLATGLLL---LLSVQPWAESGKVLVVPT--DGSHWLSMREALRDLHARGHQVVVLT-- 62

  Fly    63 SLE-----KEQLGSNYTEILIEPVYDFWHDVKLN-----FGAQHLF-----ELTRMTNYDFLKML 112
             ||     ||:.....|...|....|.:..:.|.     |..:||.     .:..|.|...:...
Human    63 -LEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHR 126

  Fly   113 EIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVV-----TTSTL 172
            ..:.|...|..:|.      :||..    ||::|.:.|:..| ..||....||.|     ....|
Human   127 SCVELLHNEALIRH------LHATS----FDVVLTDPFHLCA-AVLAKYLSIPAVFFLRNIPCDL 180

  Fly   173 GYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKN----------------SYASFYEDMDR 221
            .::.....     .|.|::|......:|.|:||:||||                .|||
Human   181 DFKGTQCP-----NPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYAS------- 233

  Fly   222 LLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAP---------LTTARPTVDAMVP 277
                      :|.|.|             :|::||:.|.|||.         :...||.:..||.
Human   234 ----------LASELF-------------QREVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVF 275

  Fly   278 VGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKF 341
            :||::....|||..:.:|.::.:.| |.:.|||||.|  .::|.:.........|.:.|.|||::
Human   276 IGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRY 338

  Fly   342 EDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMN 406
            .....|.|.:|.::.|||||.|:|.|...:.||||.|..|..|.:...|||:.:|.:.||..|..
Human   339 TGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAK 403

  Fly   407 KAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIR 471
            :....|..::|:...:|.|.|.::|..:|::.:||||:.|:|.:.:|||:||...||:|:|:|:|
Human   404 RMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMR 468

  Fly   472 HRGASHMRSAGLDLNWFQFYLLDVIAF----VAIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            |:||.|:|.|..||.|:|::.||||.|    |..:|.......:...|..:|...:.:||.::
Human   469 HKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKS 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	156/531 (29%)
		UDPGT	37..498	CDD:278624	149/506 (29%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	157/548 (29%)
		egt	<262..508	CDD:223071	90/247 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150727
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790