DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and UGT1A8

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_061949.3	Gene:	UGT1A8 / 54576	HGNCID:	12540	Length:	530	Species:	Homo sapiens

Alignment Length:	548	Identity:	162/548 - (29%)
Similarity:	263/548 - (47%)	Gaps:	52/548 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PLLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMV---TAFSLE 65
            ||...||||      ...||..|:|.| ...| ||:....:::.:|:..||:|.:|   .::.|.
Human    11 PLCVSLLLT------CGFAEAGKLLVV-PMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLG 67

  Fly    66 K------EQLGSNYT-EILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHA 123
            |      :...::|| |.|.....|| .|.:.....:.||.|...::..|..:.       ..|.
Human    68 KSLNCTVKTYSTSYTLEDLDREFMDF-ADAQWKAQVRSLFSLFLSSSNGFFNLF-------FSHC 124

  Fly   124 LRQPKVRSLIHAEQ-----KEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMG 183
                  |||.:..:     ||..||.:..:.| ....|.:|..:.:|.|..:.....:::.:...
Human   125 ------RSLFNDRKLVEYLKESSFDAVFLDPF-DACGLIVAKYFSLPSVVFARGIACHYLEEGAQ 182

  Fly   184 LITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMD-AVAREFFGPVLTEVPKV 247
            ...|.|:||...:.|:|.|:|.|||:|......|.:  ...||.|.. .:|.|.....:|.....
Human   183 CPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHL--FCQYFSKNALEIASEILQTPVTAYDLY 245

  Fly   248 KHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGS 311
            .|    .|:.||.:...|...:|.:..|:.:||::.:..||||.:.:|.::.:.| |.:.|||||
Human   246 SH----TSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGS 306

  Fly   312 NVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITH 376
            .|  .::|.:.........|.:.|.|||::.....|.|.:|.::.|||||.|:|.|...:.||||
Human   307 MV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITH 369

  Fly   377 GGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYK 441
            .|..|..|.:...|||:.:|.:.||..|..:....|..::|:...:|.|.|.::|..:|::.:||
Human   370 AGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYK 434

  Fly   442 ENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAF----VAII 502
            ||:.|:|.:.:|||:||...||:|:|:|:||:||.|:|.|..||.|:|::.||||.|    |..:
Human   435 ENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTV 499

  Fly   503 ALAGVMALSLAIRLLMGSNKKHRKAKQN 530
            |.......:...|..:|...:.:||.::
Human   500 AFITFKCCAYGYRKCLGKKGRVKKAHKS 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	151/502 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	143/477 (30%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	152/519 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150695
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690