Protein Alignment Ugt49C1 and UGT1A10

DIOPT Version :9

• Sequence 1: NP_001036565.1
• Gene: Ugt49C1 / 37421
• FlyBaseID: FBgn0034605
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 161/553 - (29%)
• Similarity: 266/553 - (48%)
• Gaps: 62/553 - (11%)

  Fly     4 PLLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMV---TAFSLE 65
            ||...||||      ...||..|:|.| ...| ||:....:::.:|:..||:|.:|   .::.||
Human    11 PLCVCLLLT------CGFAEAGKLLVV-PMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLE 67

  Fly    66 K------EQLGSNYT------EILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLK 118
            :      :...::||      |.::     |.| .:....||.:|.|...::..||.:.
Human    68 RSLNCTVKTYSTSYTLEDQNREFMV-----FAH-AQWKAQAQSIFSLLMSSSSGFLDLF------ 120

  Fly   119 TTEHALRQPKVRSLIHAEQ-----KEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHM 178
             ..|.      |||.:..:     ||..||.:..:.| ....|.:|..:.:|.|..:...:.:|:
Human   121 -FSHC------RSLFNDRKLVEYLKESSFDAVFLDPF-DTCGLIVAKYFSLPSVVFTRGIFCHHL 177

  Fly   179 SQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNY-FPKMDAVAREFFGPVLT 242
            .:......|.|:||:..:.|:|.|:|.|||.|......:.:  ...| |.....:|.|.....:|
Human   178 EEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHL--FCQYLFRNALEIASEILQTPVT 240

  Fly   243 EVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIF 306
            ......|    .|:.||.:...|...:|.:..|:.:||::.:..||||.:.:|.::.:.| |.:.
Human   241 AYDLYSH----TSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVV 301

  Fly   307 FSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVK 371
            |||||.|  .::|.:.........|.:.|.|||::.....|.|.:|.::.|||||.|:|.|...:
Human   302 FSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTR 364

  Fly   372 VFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIH 436
            .||||.|..|..|.:...|||:.:|.:.||..|..:....|..::|:...:|.|.|.::|..:|:
Human   365 AFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIN 429

  Fly   437 NVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAF--- 498
            :.:||||:.|:|.:.:|||:||...||:|:|:|:||:||.|:|.|..||.|:|::.||||.|
Human   430 DKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLA 494

  Fly   499 -VAIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
             |..:|.......:...|..:|...:.:||.::
Human   495 VVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKS 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	150/507 (30%)
		UDPGT	37..498	CDD:278624	142/482 (29%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	151/524 (29%)
		egt	<258..504	CDD:223071	90/247 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150698
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690