DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt37B1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	166/547 - (30%)
Similarity:	265/547 - (48%)	Gaps:	76/547 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIEPVYDFWH 86
            |.|:.||.::.....||.::..::.|.|.|.||.||:||.  |:...|..:...||:....|...
  Fly    19 AHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTI--LKPPSLHKDINHILVPMEEDILQ 81

  Fly    87 DVKLNFGAQ----------HLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIHAEQKEGV 141
            ......|..          .:|...|..:..|.||.::         ::||.|:.|.  |..:..
  Fly    82 AFNSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGDV---------MKQPLVKDLY--EHPDNK 135

  Fly   142 FDLLLAEQFYQEAFLALAHLYKIPVVTT-----STLGYENHMSQMMGLITPW--SFVP------H 193
            |||::...|.....|||||..|:|:|..     |.|||      ::|  .||  |:||      .
  Fly   136 FDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSFLGY------LLG--NPWEVSYVPGMSVSIK 192

  Fly   194 GFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKM--DAVAREFFG--PVLTEVPKVKHMERQI 254
            |..|    :.|..||.|...|..:   ||..:..::  ..:.||.:|  |.|   |..:.:.:.|
  Fly   193 GGKP----LGFGHRVLNLLGSMAQ---RLFMFIIELRNARIYREIYGDDPTL---PSYEDLHKNI 247

  Fly   255 SVMLLNSH----APLTTARPTVDAMVPVGGMHI-YPPKPLPADMQALLDGATEGAIFFSLGSNVQ 314
            |::...||    .|:   ||.|.|::.:||:.: ..|:.||.:|:..|..|..|||..|||||::
  Fly   248 SLIFFASHGISEGPI---RPNVPAVIEIGGIQVKEQPERLPQNMEQFLSEAPNGAILLSLGSNLK 309

  Fly   315 SKDMPVEMLRLFLQVFGSLKQRVLWKFED-ESISQLPDNVMVRKWLPQADILAHRHVKVFITHGG 378
            ...:....::....|...|:|:|:||::| ::|....:|::..||:||.|:|||.::.:||||.|
  Fly   310 EDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPGESENILYSKWVPQVDVLAHPNITLFITHAG 374

  Fly   379 LFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKEN 443
            ..|..|..::..|||.:|.:.||..|.:..|:.|:.|.....::.|:.....:.:::.|..|...
  Fly   375 KGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATA 439

  Fly   444 VQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGVM 508
            |:..|.::|||||.||::.:||:|||||:.||.|::|..:.:::.....|||.|    :.|..::
  Fly   440 VKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYA----VILGTIV 500

  Fly   509 ALSLAIRLLMG-----SNKKHRKAKQN 530
            ||....:||.|     ..|..||||.|
  Fly   501 ALCFITKLLFGLVVGKLRKNSRKAKVN 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	154/514 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	149/493 (30%)
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	161/541 (30%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	150/497 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454759
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940