DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt37C1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	154/518 - (29%)
Similarity:	265/518 - (51%)	Gaps:	62/518 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 MHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRM-- 103
            |.||  :.|.|:||.||:|   |:.:.::......:::.||.........|       ::..|
  Fly     1 MSTA--KALAEAGHNVTVV---SMMQPKVMHKDIHLIVVPVTKEQERTLEN-------QMASMAG 53

  Fly   104 -------TNYDFLKMLEIIGLKTTEHA--LRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALA 159
                   |.|..|..|:::   .|..|  |:.|:.:.:.     |..|||::...|:.:..|.:|
  Fly    54 SKNNIITTMYLLLNGLDVM---VTSQADLLKDPRFQRVF-----ETKFDLMILGSFFNDFQLGVA 110

  Fly   160 HLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKN-------SYASFYE 217
            ...|:||:....:.....:.:.:...:..|:||:.....|..|||.:|.:|       .|.:.
  Fly   111 GKLKVPVIVDWMIPSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTI-- 173

  Fly   218 DMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSH----APLTTARPTVDAMVPV 278
                ..||  |.:.:..|.|..  .::|.:..|::.||::.:.||    .|:   ||.|.|::.|
  Fly   174 ----RFNY--KFNRIYNEIFTD--KDMPTLSEMKKNISMVFVGSHLISDGPI---RPLVPAIIEV 227

  Fly   279 GGMHI-YPPKPLPADMQALLDGATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFE 342
            ||:.: ..|.|||.|::..::.:::||||.|.|||::|..:..|::.:..:|...|||.|:||:|
  Fly   228 GGIQVKEQPDPLPQDIEQFMENSSQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWE 292

  Fly   343 D-ESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMN 406
            | |:......|:..:.||||.|||||.:.|:|:||.|.....|..::.|||:.:|.:.|..||..
  Fly   293 DLENTPGNASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAA 357

  Fly   407 KAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIR 471
            ..|..||.:||..|:|||:..|.::::::.|..|.:.|::.|.::|||||.||:|.::|::||:|
  Fly   358 LMVNSGYGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLR 422

  Fly   472 HRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGVMALSLAIRL----LMGSNK-KHRKAKQ 529
            |.||.:::|..:.:.:.:.:.||:.|.|..|.:..|....|.::.    |:|..| ..||.||
  Fly   423 HHGAPNLQSPAVHMGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKKKQ 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	145/486 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	142/480 (30%)
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	149/508 (29%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	137/457 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454744
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.840