DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt35C1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001097744.1	Gene:	Ugt35C1 / 53507	FlyBaseID:	FBgn0040256	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	179/508 - (35%)
Similarity:	288/508 - (56%)	Gaps:	27/508 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIEPVYDFWH 86
            :|.:||||...|||:|.::...:.::.|...|||||::.||. .||.....:.|.|  ..::|..
  Fly    21 SESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVINAFK-NKETPNMRFIEAL--KAHEFAD 82

  Fly    87 DVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFY 151
            ::........|::.....:|...|.:::        .:....|:.|:::.:   .|||:|||..:
  Fly    83 EMMSLLNVPLLWQQLNAMDYILNKFIDV--------TMEDEGVQRLLNSGE---TFDLVLAEMLH 136

  Fly   152 QEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFY 216
            .|...|.|..:...:|..|:.|.:..:.:..|.|:|.|:.|....|.||||:||||::|.|....
  Fly   137 MEPMYAFAQHFNATLVGFSSFGTDRTIDEAAGNISPISYNPLVTSPRTDRMTFLERLENHYEVIV 201

  Fly   217 EDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQI----SVMLLNSHAPLTTARPTVDAMVP 277
            ||:.|...:.|.|..|.:::|       |..|....::    |::||..|..|:..||.:..|:.
  Fly   202 EDIHRHFVHLPHMRNVYKKYF-------PNAKKTLEEVMDSFSLILLGQHFSLSYPRPYLPNMIE 259

  Fly   278 VGGMHI-YPPKPLPADMQALLDGATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKF 341
            |||||| :.|||||.|::..::|:..|.|:||:||||:|||:|.|.....|:.|..|||||||||
  Fly   260 VGGMHISHKPKPLPEDIKQFIEGSPHGVIYFSMGSNVKSKDLPQETRDTLLKTFAKLKQRVLWKF 324

  Fly   342 EDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMN 406
            ||:.:...|.||:::||.||.|||||.:||:||:||||..:.|.|::..|:||:|.:.|||:|:.
  Fly   325 EDDDMPGKPANVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESVYFGKPILGLPCFYDQHMNVQ 389

  Fly   407 KAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIR 471
            :|...|:.:.|...::.:|.|..::..|:.:.:|.:....:|:.:||:|......||:|.|||||
  Fly   390 RAQRVGFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSAVDRAVWWTEYVIR 454

  Fly   472 HRGASHMRSAGLDLNWFQFYLLDVIAFV-AIIALAGVMALSLAIRLLMGSNKK 523
            |.||.|:|:...|||:.|...||.:|.: |:..|..::.::|:.:||.|..:|
  Fly   455 HNGAPHLRATSRDLNFIQLNSLDTLAVILAVPLLLALLIVTLSCKLLGGKKQK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	173/487 (36%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	163/465 (35%)
Ugt35C1	NP_001097744.1	egt	1..470	CDD:223071	167/469 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.860