DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt35E1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	178/542 - (32%)
Similarity:	298/542 - (54%)	Gaps:	50/542 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNY 73
            ||..|.||       |::|||::..|..||:......::.|...||::|.|:.|..|:.
  Fly    12 LLFPGFLY-------GARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEP------ 63

  Fly    74 TEILIEPVYDFWHDVKLNFGAQHLFELTRMTN-YDFLKMLEIIGLKTTEHALRQPKVRSLIHAEQ 137
                ::.:||.:....||...:.|.::|...| ::|...........|:.......||..|....
  Fly    64 ----VKNIYDIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREILRPG 124

  Fly   138 KEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFV--PHGFM---- 196
            | ..|||::.:.:..:||.:||..::.|::..:..|.:..:.:|:|..:|.|::  |..::
  Fly   125 K-AQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLD 188

  Fly   197 PFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNS 261
            .|..|::.:..|..|:.:::      ..|..|.:|:.:::| |.:.|...:..:.:.|:::|:|.
  Fly   189 TFGGRVAHVVEVAISWFNWH------WRYEQKHEALYKKYF-PKIAETKPLSEISQDIALVLVNQ 246

  Fly   262 HAPLTTARPTVDAMVPVGGMHI-YPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLR 324
            |..|...||.|..::.|||||| ..||.|..|::..:.|:.| |.|:||||:||::|:|..:..|
  Fly   247 HFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKR 311

  Fly   325 LFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYA 389
            :.::.||||.||||||||||.:..:|.||:|||||||.|:|||..||:||||||:..|.|.:||.
  Fly   312 ILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYG 376

  Fly   390 VPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDR 454
            .||||:||:.||..|::.....|:.:||::..:|.:.|:.::.||:....::...:.....:||:
  Fly   377 KPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQ 441

  Fly   455 PLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGVMALSLAI----- 514
            |::|.::||:|..||:||:||.|||.||..|::|..:.|||:..|.::.|..::|:.|.|
  Fly   442 PMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVC 506

  Fly   515 --------RLLMGSNKKHRKAK 528
                    ||::   ||.||.|
  Fly   507 KISKNISTRLVV---KKQRKQK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	162/490 (33%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	156/469 (33%)
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	154/473 (33%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	156/468 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454702
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8488
SonicParanoid	1	1.000	-	-		X13
	11	10.820