DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt35D1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	166/521 - (31%)
Similarity:	285/521 - (54%)	Gaps:	28/521 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PLLFGL--LLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEK 66
            |.:|.|  ||.|  ||     ||::||||:..|..||:......::.|...||::|.|:.:. ::
  Fly     2 PPIFLLVCLLPG--YS-----EGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYP-QR 58

  Fly    67 EQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMT--NYDFLKMLEIIGLKTTEHALRQPKV 129
            |.. .|..:|.:..|::.:::|      ..:....|.|  :.||:.  |.: |..|:..|....|
  Fly    59 EPF-RNIHDIPVPEVFENFNEV------LRIASTPRSTWQSSDFIN--EYV-LNLTKTVLNNEGV 113

  Fly   130 RSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHG 194
            |..|...||.. |||::.:.:..:....||..:..|::..::.|.:..:.::||.::|.|::...
  Fly   114 RRDILGPQKPH-FDLVIMDLWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNVSPISYLQSP 177

  Fly   195 FMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLL 259
            ...|.|..::.||:.:.....:..|:....:..|.:.:..:|| |.:.|...:..:.|...::|:
  Fly   178 SSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFF-PSVAERKPLSEISRNFDLVLV 241

  Fly   260 NSHAPLTTARPTVDAMVPVGGMHI-YPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEM 322
            |.|..|...||.|..|:.|||:|: :..:.|.|::...:.||.| |.|:||||:||:||.:..:.
  Fly   242 NQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDR 306

  Fly   323 LRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVH 387
            .::.|:.|.||.||::||||||.:...|.||.:.||.||..||||.:||:|||||||..|.|.:|
  Fly   307 RKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIH 371

  Fly   388 YAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFR 452
            :..||||:|...||..||:.....|..:.|:.:.:|.|..|.::.:|:.|.:::|..:..:..:|
  Fly   372 HGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYR 436

  Fly   453 DRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIA--FVAIIALAGVMALSLAIR 515
            |:|::|.::|::|.|||:.|:||:||:.||.||.:.:::.|||..  .|..:.:.|::...|.:.
  Fly   437 DQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMT 501

  Fly   516 L 516
            |
  Fly   502 L 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	155/487 (32%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	147/466 (32%)
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	153/479 (32%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	151/486 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454705
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790