DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and Ugt303B1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	153/536 - (28%)
Similarity:	253/536 - (47%)	Gaps:	57/536 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKE------ 67
            |.|:..|..|.:.|:.:.||.::.:...|.|.:...|:|.|...||.||::|...:..:
  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVRH 72

  Fly    68 ----QLGSNYTEIL-IEPVYDF----WHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHA 123
                ||.....|:| .:.|.||    |.:..|.  |:.||                   ..:...
  Fly    73 IRVAQLNERIKEMLESDQVLDFMINKWTESALT--AKALF-------------------NASNDI 116

  Fly   124 LRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPW 188
            |..|.|:.::|  .|...|||::.|....:|...|...|...::..|::....|..::.|...|.
  Fly   117 LSDPGVQRMLH--DKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNPAPS 179

  Fly   189 SFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYF---PKMDAVAREFFGPVLTEVPKVKHM 250
            .:.|...:.|:...|...||.| :....|  ::|:||.   |....:.::|||   ....|:..:
  Fly   180 IYEPISPVGFSLETSLFSRVYN-WIHIME--EKLVNYLILRPAQLHLFQKFFG---YSAQKMNEL 238

  Fly   251 ERQISVMLLNSHAPLTTARPTVDAMVPVGGMHI-YPPKPLPADMQALLDGATEGAIFFSLGSNVQ 314
            ..:.|:||:|||..:...|.....::.|||:|: .||:|...::|..||.|..|.|:||:|:::.
  Fly   239 RSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYFSMGNDIL 303

  Fly   315 SKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGL 379
            .|.:|..:..|.||.|.:|.:.::||.|...:....|||.|.:..||..||.|.:|::|||:|||
  Fly   304 IKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGL 368

  Fly   380 FGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENV 444
            ....|.|...|||||:|.:.||..||....|.|.|..:...|:.::.|..::..::.|.:|....
  Fly   369 LSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKA 433

  Fly   445 QRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLD-VIAF--------VA 500
            :.:|..|:|||:.|..:||:|.||.:|:|..:.||....::...::|.:| ::||        .:
  Fly   434 KEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAAS 498

  Fly   501 IIALAGVMALSLAIRL 516
            :|.|...:.|...|||
  Fly   499 LIFLVYTLFLKYRIRL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	144/509 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	138/480 (29%)
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	136/469 (29%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	141/498 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454714
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790