DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt303B3

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	141/513 - (27%)
Similarity:	249/513 - (48%)	Gaps:	31/513 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQL 69
            :||.|.|...||.  :..:.:.||.::::...||.::...|.:.||:.||.||::|...:..:..
  Fly    10 VLFCLFLQKDLYQ--DSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDIE 72

  Fly    70 GSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNY---DFLKMLEIIGL--KTTEHALRQPKV 129
            |..:..:           .|||...|.:.|..::.::   .::..|.::.:  ..:...|....|
  Fly    73 GVRHIRV-----------PKLNQRVQEMIEGDQILDFFGSKWIASLMVVSMLYNMSSDILSDKGV 126

  Fly   130 RSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHG 194
            :.::  :.:...|||::.|....||...:...|...::..|.........::.|...|....|..
  Fly   127 QKML--QNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNFAPSINDPIS 189

  Fly   195 FMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLL 259
            .:.::...|.|.::.|......|.:.:.|.:.|....:.::||.  .:| .|..:|..:.||:|:
  Fly   190 SLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFN--FSE-QKFYNMREKYSVILV 251

  Fly   260 NSHAPLTTARPTVDAMVPVGGMHI-YPPKPLPADMQALLDGATEGAIFFSLGSNVQSKDMPVEML 323
            |:|..:...|..|..::.|||:|: .|.:|..:.:|..:|.|..|.|:||:|..:..:.:|.:|.
  Fly   252 NNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMDDAEHGVIYFSMGQEIMVQFLPEDMQ 316

  Fly   324 RLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHY 388
            :..::.....||||:||.|..::....|||.|.:..||..:|||.:.::|||:|||....|.|:.
  Fly   317 QNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYS 381

  Fly   389 AVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRD 453
            .||:||:|.:.||.:|:....|.|.|..|....:|.|||..::.:|:.|..|....:::|..|||
  Fly   382 GVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRD 446

  Fly   454 RPLEPRKSAVYWIEYVIRHRGASHMR----SAGLDLNWFQFYLLDV---IAFVAIIAL 504
            ||:.|..:||:|.||.:|::.|||||    ...|...|....||.:   |.|.::|.|
  Fly   447 RPMSPLDTAVWWTEYALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	134/494 (27%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	130/473 (27%)
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	128/473 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454720
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790