DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	170/570 - (29%)
Similarity:	261/570 - (45%)	Gaps:	91/570 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PL--LFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVT------ 60
            ||  |.||||   |...|..|||.|:| |:...| ||::....::|||...|||..::.
  Rat     8 PLRGLSGLLL---LLCALPWAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLAPEVTVH 67

  Fly    61 ------------AFSLEKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLE 113
                        ||...||:.   ..|||        .:.|..|..||..:....|.....|..:
  Rat    68 MKGEDFFTLQTYAFPYTKEEY---QREIL--------GNAKKGFEPQHFVKTFFETMASIKKFFD 121

  Fly   114 IIGLKTTEHALRQPKVRSLIH-----AEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVV---TTS 170
                      |......:|:|     .:.....||::|.:..:....| ||...:||.|   .:.
  Rat   122 ----------LYANSCAALLHNKTLIQQLNSSSFDVVLTDPVFPCGAL-LAKYLQIPAVFFLRSV 175

  Fly   171 TLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVARE 235
            ..|.:...:|..   .|.|::|:.....:|.|:||:||||.....      .|.|...:.....|
  Rat   176 PCGIDYEATQCP---KPSSYIPNLLTMLSDHMTFLQRVKNMLYPL------TLKYICHLSITPYE 231

  Fly   236 FFGPVLTEVPKVKHMERQISVMLLNSHAPL---------TTARPTVDAMVPVGGMHIYPPKPLPA 291
            .....|        ::|::|::.:.|||.:         ...||.:..||.:||::....|||..
  Rat   232 SLASEL--------LQREMSLVEVLSHASVWLFRGDFVFDYPRPIMPNMVFIGGINCVIKKPLSQ 288

  Fly   292 DMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMV 355
            :.:|.::.:.| |.:.|||||.|  .::|.:......:..|.:.|.|||::.....|.|..|.::
  Rat   289 EFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTIL 351

  Fly   356 RKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQ 420
            .|||||.|:|.|...:.||||.|..|..||:...|||:.:|.:.||..|..:....|..::|:..
  Rat   352 VKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVL 416

  Fly   421 SITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDL 485
            .:|.:.|.::|..:|:|.:||||:.|:|.:.:|||:||...||:|:|||:||:||.|:|.|..||
  Rat   417 EMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDL 481

  Fly   486 NWFQFYLLDVIAFVAIIALAGVM----ALSLAIRLLMGSN---KKHRKAK 528
            .|:|::.||||.|:..|.|..|.    :.:...|...|..   ||..|:|
  Rat   482 TWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	153/517 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	144/496 (29%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	154/538 (29%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	93/247 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860