DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt301D1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	221/526 - (42%)
Similarity:	323/526 - (61%)	Gaps:	22/526 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIE 79
            |...||...||:||.:..||..||::.......:|:..||.||.|.....:...  .|.|||:|.
  Fly    15 LIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPH--ENLTEIIIS 77

  Fly    80 PVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIHAEQKEGVFDL 144
            |.:    |:..:|..:::|.:..:::::.|::...|||.|||||.:.|||:.||  |.|:..:||
  Fly    78 PSF----DIPKHFPKENIFSMQFVSDFNNLELWWTIGLMTTEHAFKDPKVKKLI--ESKDDHYDL 136

  Fly   145 LLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVK 209
            ::.|||:.||||.....:..||||..|:||.:::...||::||||.:||..:..||||:|.:|..
  Fly   137 VIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSLIPHLLLSHTDRMTFGQRAY 201

  Fly   210 NSYASFYEDMDRLLNYFPKMDAVAREFF-GPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVD 273
            |:|.|.|:.:.|...|.|||..:|.::| |.:...:|.|..:||.||::|:|:|..:...||::.
  Fly   202 NAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMP 266

  Fly   274 AMVPVGGMHIYPPKPLPADMQALLDGATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVL 338
            .::.|||.||..||.||.|:|..||.||.|.|:||:||.|:|.|:|.|...|.|:.||.|||:|:
  Fly   267 GLIDVGGAHIQKPKQLPTDLQNFLDNATYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVI 331

  Fly   339 WKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHL 403
            ||||::||..||.|||::||:||.|||||.:||:||||||:||||||:::.||||.:|.|.|||.
  Fly   332 WKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHR 396

  Fly   404 NMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEY 468
            |..|:|..|||.||.|..:|.:.|..:::.||::..||.:...||..|||.|:.|...|.:||||
  Fly   397 NTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEY 461

  Fly   469 VIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGVMALSLAIRLLM----------GSNKK 523
            :||||||.|::|.|..:...|:.||||:   ..:.|...:|:.|..|::.          .|||.
  Fly   462 IIRHRGARHLKSHGAFIPLHQYLLLDVL---GCLLLGAFLAIWLPWRMIRRVHKWWLKGESSNKL 523

  Fly   524 HRKAKQ 529
            :...|:
  Fly   524 NEGKKR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	210/482 (44%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	204/461 (44%)
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	208/475 (44%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	199/453 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47873at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.870