DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	164/545 - (30%)
Similarity:	254/545 - (46%)	Gaps:	77/545 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIEPVYDFWH 86
            |:..::|.| ...| ||:.....::.:|...||:|.:|                  |..|  .||
  Rat    23 AQAGRLLVV-PMDG-SHWFTMQMIVEKLSHRGHEVVVV------------------IPEV--SWH 65

  Fly    87 DVK-LNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVR-----SLIHAEQKEGVFDLL 145
            ..| |||         .:..|.....||.:.......|..|.|.:     ||:....| |.|:||
  Rat    66 MGKSLNF---------TVKTYSVSYTLEDLNYHFKFFAHNQWKTQEVGMFSLLKHSGK-GFFELL 120

  Fly   146 ------------LAEQFYQEAF------------LALAHLYKIPVVTTSTLGYENHMSQMMGLIT 186
                        |.|...|.:|            |.||..:.:|.|..|...:.:::.:.....:
  Rat   121 FSHCRSLFKDKKLVEYLKQSSFDAVFLDPFDVCGLILAKYFSLPSVVFSGGIFCHYLDEGAQCPS 185

  Fly   187 PWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHME 251
            |.|:||.....|||.|:|.|||.| :.|:.::. ....||.|   .|.|....||.....::.:.
  Rat   186 PPSYVPRILSKFTDTMTFKERVWN-HLSYMKER-AFCPYFFK---TAVEIASEVLQTPVTMRDLF 245

  Fly   252 RQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQS 315
            ..:|:.:..:...|...||.:..||.:||::.:..|||..:.:|.::.:.| |.:.|||||.|
  Rat   246 SPVSIWMFRTDFVLEFPRPVMPNMVYIGGINCHQGKPLSKEFEAYVNASGEHGIVVFSLGSMV-- 308

  Fly   316 KDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLF 380
            .::|.:......:..|.:.|.|||::.....|.|..|.::.|||||.|:|.|...:.||||.|..
  Rat   309 SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSH 373

  Fly   381 GTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQ 445
            |..||:...|||:.:|.:.||..|..:....|..::|:...:|.:.|.::|..:|:|.:||||:.
  Rat   374 GIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIM 438

  Fly   446 RVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGVM-- 508
            |:|.:.:|||:||...||:|:|||:||:||.|:|.|..||.|:|::.||||.|:..|.|..|.
  Rat   439 RLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIV 503

  Fly   509 --ALSLAIRLLMGSN---KKHRKAK 528
              :.:...|...|..   ||..|:|
  Rat   504 YKSCAYGCRKCFGGKGRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	156/512 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	150/491 (31%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	159/533 (30%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	93/242 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860