DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	161/554 - (29%)
Similarity:	278/554 - (50%)	Gaps:	62/554 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFGLLLTGTLYSQLELAEGSKILAVYAFPGK-SHFMMHTALIRELVESGHQVTMV--TAF----- 62
            :|.|||....:. |..|:..|:|   .:|.: ||:|....::.|||:.||:||::  :|:
  Rat     6 IFALLLLQISFC-LRSAKCGKVL---VWPMEFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDP 66

  Fly    63 -------------SLEKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEI 114
                         |:.|::|...:.:::     |.|           .:||.|.|...|..:|:.
  Rat    67 KKSPDLKFETFPTSVSKDELEKYFIKLV-----DAW-----------TYELQRDTCLSFSPLLQN 115

  Fly   115 IGLKTTEHAL---RQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYEN 176
            :..:.:::.|   :.......:.|:.:|..||:||::.......| :|.:..||.:.:......:
  Rat   116 MMDEFSDYYLSVCKDAVSNKQLMAKLQESKFDVLLSDPVAACGEL-IAEVLHIPFLYSLRASPGH 179

  Fly   177 HMSQMMG-LITPWSFVPHGFMPFTDRMSFLERVKNS----YASFYEDMDRLLNYFPKMDAVAREF 236
            .:.:..| .|.|.|:||........:|:|::||||.    |..|:..|....|:.|        |
  Rat   180 KIEKSSGRFILPPSYVPVILSGLGGQMTFIDRVKNMICMLYFDFWFHMFNAKNWDP--------F 236

  Fly   237 FGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGAT 301
            :..:|.....:.....:..:.|:.|:..|....||:..:..:||:...|.||||.|::..:..:.
  Rat   237 YTEILGRPTTLAETMGKAEMWLIRSYWDLEFPHPTLPNVDYIGGLQCKPAKPLPKDIEDFVQSSG 301

  Fly   302 E-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADIL 365
            | |.:.|||||.|.|  |..|...........:.|:|||||:.:..:.|..|..|.|||||.|:|
  Rat   302 EHGVVVFSLGSMVSS--MTEEKANAVAWALAQIPQKVLWKFDGKIPATLGPNTRVYKWLPQNDLL 364

  Fly   366 AHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHS 430
            .|...|.|:||||..|..|.:::.:||:|||.:.:||.|:...|..|.|::|:.:::::..|.::
  Rat   365 GHPKTKAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNA 429

  Fly   431 LDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDV 495
            |.::|:|..||:|...:|.|..|:|::|...|::|||||:||:.|.|:|..|.:|.|:|::.|||
  Rat   430 LKEVINNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLRPLGHNLPWYQYHSLDV 494

  Fly   496 IAF-VAIIALAGVMALSLAIRLLMGSNKKHRKAK 528
            |.| :|.:|:...:|:...:.:.....||.:|.|
  Rat   495 IGFLLACLAVIAALAVKCFLFIYRFFAKKQKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	150/512 (29%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	144/489 (29%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	153/532 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760