DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and F10D2.8

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001309630.1	Gene:	F10D2.8 / 266913	WormBaseID:	WBGene00017334	Length:	494	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	119/540 - (22%)
Similarity:	217/540 - (40%)	Gaps:	112/540 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SKILAVYAFP--------GKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIEPV 81
            |.|.:.|::.        |.||......:...|.::||.||..|...:||.: ..:||::..:.|
Worm     9 SLIYSTYSYNFLVFCPLFGHSHTKFFATIADALTDAGHNVTFFTPTIVEKYR-NVSYTKLTKDVV 72

  Fly    82 Y--------------------DFWHDVK--LNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHAL 124
            :                    .||.:..  .|.||..|:..:...|..|..:::.:.:||
Worm    73 HMDAPKKLMEYGEQMESADFSRFWTEDSSFYNVGAADLYRCSIRLNGLFKSLMDYLNIKT----- 132

  Fly   125 RQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPWS 189
                                                     .:.:.:|.::.::|:.:|.....|
Worm   133 -----------------------------------------FIPSLSLTHDVYLSKAIGEPVMPS 156

  Fly   190 FVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQI 254
            .|.....||.|::|.|||..|::|..|  :|.:|.| |..:.::..:     ||: .::.:|.:.
Worm   157 VVSDVCSPFGDKLSLLERAFNAFAVPY--IDIVLGY-PVHNTLSAPY-----TEI-DIRTIEPEA 212

  Fly   255 SVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQAL----LD-------GATEGAIFFS 308
            |.:.|||:..|...|||:...|.:||:.:        |:..|    ||       ...|..:..|
Worm   213 SFLFLNSNPFLDFPRPTLTKTVEIGGITV--------DLNQLKSQQLDSKWSDILNLREKTMLVS 269

  Fly   309 LGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFEDESISQLP---DNVMVRKWLPQADILAHRH 369
            .||...|||||:|..::........|. ..:||:|...|....   .|:...||:||..:||:|.
Worm   270 FGSVFFSKDMPLENKKVIANSMTEFKNVTFIWKYEGNDIEDFARGIQNIHFVKWVPQTALLANRR 334

  Fly   370 VKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVL--GGYAISLHFQSITEEILRHSLD 432
            :..|.||.||....|..:...|.:..|.:.||..|....|.  |...:|.:....:::|: .:..
Worm   335 LSAFFTHAGLGSINEVSYLGKPSILCPLFADQMRNAKMLVRHNGSIELSKYDLGNSKKII-EAFQ 398

  Fly   433 QLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIA 497
            .::.:.:|.||.|::::...::|::|.|..|...|:..|......:......:::.:::||||..
Worm   399 AILFDSSYAENAQKLAEQLENQPIKPEKMMVKHAEFAARFGRLPSLDPYSRKMSFVEYFLLDVAT 463

  Fly   498 FVAIIALAGVMALSLAIRLL 517
            ...::....|..|:..::.|
Worm   464 ICVLVLACVVFVLTRVVQFL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	116/525 (22%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	112/499 (22%)
F10D2.8	NP_001309630.1	UDPGT	29..492	CDD:278624	115/520 (22%)
F10D2.8	NP_001309630.1	Glycosyltransferase_GTB_type	<215..461	CDD:299143	64/254 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740