DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	160/523 - (30%)
Similarity:	268/523 - (51%)	Gaps:	59/523 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHFMMHTALIRELVESGHQVTMV--TAF------------------SLEKEQLGSNYTEILIEPV 81
            ||:|....::.|||:.||:||::  :|:                  |:.|::|.:.:.:::
  Rat    34 SHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKKSPDLKFETFPTSVSKDELENYFIKLV---- 94

  Fly    82 YDFWHDVKLNFGAQHLFELTRMTNYDFLKMLE--IIGLKTTEHALRQPKV-RSLIHAEQKEGVFD 143
             |.|           .:||.|.|...:..:|:  |.|......:|.:..| ...:.|:.:|..||
  Rat    95 -DVW-----------TYELQRDTCLSYSPLLQNMIDGFSDYYLSLCKDTVSNKQLMAKLQESKFD 147

  Fly   144 LLLAEQFYQEAFLALAHLYKIPVVTTSTL--GYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLE 206
            :||::.......| :|.:..||.:.:...  ||:...|....::.| |:||.........|:|::
  Rat   148 VLLSDPVAACGEL-IAEVLHIPFLYSLRFSPGYKIEKSSGRFILPP-SYVPVILSGMGGPMTFID 210

  Fly   207 RVKNSYASFYEDMDRLLNYFPKMDAVARE-FFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARP 270
            ||||...:.|.|.     :|...:|...: |:..:|.....:.....:..:.|:.|:..|....|
  Rat   211 RVKNMICTLYFDF-----WFHMFNAKKWDPFYSEILGRPTTLAETMGKAEMWLIRSYWDLEFPHP 270

  Fly   271 TVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLK 334
            |:..:..:||:...||||||.||:..:..:.| |.:.|||||.|.|  |..|...........:.
  Rat   271 TLPNVDYIGGLQCRPPKPLPKDMEDFVQSSGEHGVVVFSLGSMVSS--MTEEKANAIAWALAQIP 333

  Fly   335 QRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYC 399
            |:|||||:.::.:.|..|..|.|||||.|:|.|...|.|:||||..|..|.:::.:||:|||.:.
  Rat   334 QKVLWKFDGKTPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMVGIPMFG 398

  Fly   400 DQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVY 464
            :||.|:...|..|.|::|:.:::::..|.::|.::|:|..||:|...:|.|..|:|::|...||:
  Rat   399 EQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFYKKNAVWLSTIHHDQPMKPLDKAVF 463

  Fly   465 WIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFV----AIIALAGVMALSLAIRLLMGSNKKHR 525
            |||:|:||:||.|:|..|.:|.|:|::.||||.|:    |:||:..|.:.....||.:   ||.:
  Rat   464 WIEFVMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCSAVIAVLTVKSFLFIYRLFV---KKEK 525

  Fly   526 KAK 528
            |.|
  Rat   526 KMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	152/497 (31%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	149/487 (31%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	158/520 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344215
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690