DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt2b

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_113721.5	Gene:	Ugt2b / 24862	RGDID:	3936	Length:	530	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	157/525 - (29%)
Similarity:	261/525 - (49%)	Gaps:	63/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHFMMHTALIRELVESGHQVTM--------------------VTAFSLEKEQLGSNYTEILIEPV 81
            ||:|....::.|||:.||:||:                    :.:.|:.|::|.:::.::|
  Rat    34 SHWMNIKIILDELVQRGHEVTVLKPSAYFFLDPKKSSDLKFEIFSTSISKDELQNHFIKLL---- 94

  Fly    82 YDFWHDVKLNFGAQHLFELTRMTNYDFLKMLE-------IIGLKTTEHALRQPKVRSLIHAEQKE 139
             |.|           .:||.|.|...:..:|:       ...|...:.|:...::.:.:    :|
  Rat    95 -DVW-----------TYELPRDTCLSYSPILQNLVYEFSYFYLSICKDAVSNKQLMTKL----QE 143

  Fly   140 GVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMG-LITPWSFVPHGFMPFTDRMS 203
            ..||:|.|:.......| :|.|..||.:.:.:....:.:.:.:| .|.|.|:||........:|:
  Rat   144 SKFDVLFADPVASCGDL-IAELLHIPFLYSLSFSPGHKLEKSIGKFILPPSYVPVILSGLAGKMT 207

  Fly   204 FLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTA 268
            |::||||.....|.|....:....:.|.    |:..:|.....|.....::.:.|:.|:..|...
  Rat   208 FIDRVKNMICMLYFDFWFEILRHKEWDT----FYSEILGRPTTVDETMSKVEIWLIRSYWDLKFP 268

  Fly   269 RPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGS 332
            .||:..:..:||:|..|.||||.||:..:..:.| |.:.|||||.|  .:|..|...........
  Rat   269 HPTLPNVDYIGGLHCKPAKPLPKDMEEFVQSSGEHGVVVFSLGSMV--SNMTEEKANAIAWALAQ 331

  Fly   333 LKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPF 397
            :.|:|||||:.::.:.|..|..|.|||||.|||.|...|.|:||||..|..|.:::.:||:|||.
  Rat   332 IPQKVLWKFDGKTPATLGPNTRVYKWLPQNDILGHPKTKAFVTHGGANGLYEAIYHGIPMIGIPL 396

  Fly   398 YCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSA 462
            :.||..|:...|..|.|:||:.:::::.....:|:::|.|..||:||..:|.|..|:|::|...|
  Rat   397 FGDQPDNIAHMVAKGAAVSLNIRTMSKLDFLSALEEVIDNPFYKKNVMLLSTIHHDQPMKPLDRA 461

  Fly   463 VYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFV----AIIALAGVMALSLAIRLLMGSNKK 523
            |:|||:::||:||.|:|..|.:|.|:|::.||||.|:    |:||...|..|....|..:   ||
  Rat   462 VFWIEFIMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCFAVIAALTVKCLLFMYRFFV---KK 523

  Fly   524 HRKAK 528
            .:|.|
  Rat   524 EKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	149/499 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	146/489 (30%)
Ugt2b	NP_113721.5	UDPGT	24..527	CDD:278624	155/522 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860