DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	527	Identity:	152/527 - (28%)
Similarity:	261/527 - (49%)	Gaps:	46/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTA----------FSLEKEQL 69
            |:|.:.:|..:||:.|.....:||..:...|...|.|.||...::.:          :||::
Mouse    11 LWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVLLLSEGRDIAPSNHYSLQR--- 72

  Fly    70 GSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIH 134
               |..|......|.:...|:    :::|. .|:|..:.:.:|:    ..|::.......::||.
Mouse    73 ---YPGIFNSTTSDAFLQSKM----RNIFS-GRLTAVELVDILD----HYTKNCDMMVGNQALIQ 125

  Fly   135 AEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTST-LGYENHMSQMMGLITPWSFVPHGFMPF 198
            ..:|| .|||||.:......|: :|||..:.....|| |.|...    :|...|.::||......
Mouse   126 GLKKE-KFDLLLVDPNDMCGFV-IAHLLGVKYAVFSTGLWYPAE----VGAPAPLAYVPEFNSLL 184

  Fly   199 TDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHA 263
            ||||:||||:||:.......:.......||.:.:.:::   .|.....:..:....|:.:|.:..
Mouse   185 TDRMNFLERMKNTGVYLISRIGVSFLVLPKYERIMQKY---NLLPAKSMYDLVHGSSLWMLCTDV 246

  Fly   264 PLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFL 327
            .|...|||:..:|.|||:...|..|||.|:|..:.||.| |.:..|.|:.|  |.:..::.....
Mouse   247 ALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVSGAQEHGFVLVSFGAGV--KYLSEDIANKLA 309

  Fly   328 QVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPM 392
            ...|.|.|:|:|:|.......|.:|..:.:||||.|:|.|.:::.|::||||....|.:::.||:
Mouse   310 GALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPV 374

  Fly   393 LGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLE 457
            :|||.:.|.:..|.:....|..|.|.:.::||..|..:|.::|:|.:|::..|::|:|.:|:|..
Mouse   375 VGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGH 439

  Fly   458 PRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAII-ALAGVMALSLAIRLLMGSN 521
            |.....|||:|::||.||.|:|||...:::.|::||| ||||.:: |:.....||...:.:
Mouse   440 PVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLD-IAFVLLLGAVLLYFILSYVTKFI---- 499

  Fly   522 KKHRKAK 528
              :||.|
Mouse   500 --YRKIK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	144/494 (29%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	137/472 (29%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	146/513 (28%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840815
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790