DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt-54

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_501996.2	Gene:	ugt-54 / 188885	WormBaseID:	WBGene00012013	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	526	Identity:	139/526 - (26%)
Similarity:	233/526 - (44%)	Gaps:	66/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQL 69
            ||..|:|.|       .|....||...:...:||...|...|:.|::.||.|.:|.|...|..:|
Worm     4 LLGFLILPG-------FANCLNILFYVSVIAQSHIPFHNTAIKVLLDRGHTVDLVIAQLNEMVKL 61

  Fly    70 ------GSNYTEILIEPVYDFWHDVKLNF---GAQHLFEL---TRMTNYDFLKMLEIIGLKTTEH 122
                  |.|||....:|          ||   .|.||.::   ..:...:|| ..:.:.....|.
Worm    62 KFPNGVGKNYTFGYEDP----------NFYRKNAGHLSDIFVEKPIPMAEFL-TFDDMTFNLCET 115

  Fly   123 ALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIP----VVTTSTLGYENHMSQMM- 182
            .::.|.:.:.|    |:|.:|:.|:.. |......|.|...:|    :|.|...     ..|::
Worm   116 VVKDPNLLNYI----KQGNYDIGLSSD-YDPCANILMHAGGVPSKASMVPTPLF-----QPQIVS 170

  Fly   183 -GLITPWS-----FVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVL 241
             ||.:|.|     ..|.|...|.:|:..|  ::::| :.|....||:.   |.:.:..|.|||..
Worm   171 AGLPSPASVYGTVLYPKGDDSFFNRLFHL--IRHTY-NIYFVAPRLME---KYNNLLLETFGPTF 229

  Fly   242 TEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATEGAIF 306
               |..:.:||.:.::|:||:..:...||....:..:|||.....:||..:...:|..:.:|.:.
Worm   230 ---PSAEEIERNVDIILVNSNEIIEKPRPVSHKIKYIGGMGKKKAQPLNKEFNDILATSNKGVVL 291

  Fly   307 FSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKF----EDESISQLPDNVMVRKWLPQADILA 366
            ||.|:.|.:..:|:|:.:.|:..|..... ..|||:    :|..:.....|:...:||||.|:|.
Worm   292 FSFGTQVATSKVPIEIRKNFVTAFKHFPDFSFLWKYDNLTDDAELFADSSNIHRVEWLPQTDLLG 356

  Fly   367 HRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSL 431
            ...||.||:|.||....|.....:|:|.:|.:.||..|...||.....:.:....:|.|.|.::|
Worm   357 DNRVKAFISHMGLNSFLETSAAGIPVLAVPLFIDQQHNALNAVSRDIGVIVERHQLTVENLVNAL 421

  Fly   432 DQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASH-MRSAGLDLNWFQFYLLDV 495
            .:|::|..|.||.:.:|.:..::|.:..:..|.|:||..::.|... |...|.:|..|.:|.:||
Worm   422 QKLLYNPKYGENAKMISKMMNEKPEQSERLFVDWVEYAAKNPGLHKIMNLPGAELTPFWYYSVDV 486

  Fly   496 IAFVAI 501
            |..|.:
Worm   487 ILIVVL 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	134/509 (26%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	130/489 (27%)
ugt-54	NP_501996.2	UDPGT	35..507	CDD:278624	128/488 (26%)
ugt-54	NP_501996.2	egt	<218..498	CDD:223071	79/278 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5915
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.760