DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt-8

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504315.1	Gene:	ugt-8 / 186768	WormBaseID:	WBGene00019234	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	549	Identity:	133/549 - (24%)
Similarity:	229/549 - (41%)	Gaps:	69/549 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQ- 68
            ||..||:.|::..:       .||......|.||....:.:...:.:.||.||:...|.:..:.
Worm     6 LLSILLVLGSVSCK-------NILIFNPIFGLSHVKFISKMANIIADHGHNVTLFQPFHIALKNT 63

  Fly    69 ---LGSNYTEIL--IEPVYD------------FWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIG 116
               :.:.|.||:  ....||            ||....:|......|.:.:....:|
Worm    64 EGLIKNKYIEIINYYPDHYDELLKTETATFPAFWDSHLMNNPVLSAFMIPKAIAGEF-------- 120

  Fly   117 LKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQM 181
             :.|...|.:.||..   .:.|...||::::|.| :...:.:||:..:|.:...:.......:.:
Worm   121 -ERTATQLLKDKVAL---DDLKSRNFDVIISETF-ELTGMYIAHMLNVPCIPVWSAVRFTIFNNI 180

  Fly   182 MGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFY-----EDMDRLLNYFPKMDAVAREFFGPVL 241
            .|..:...:....|........|::|:.:.|.:|:     :.|.:..|.|.: .||.|
Worm   181 FGQPSSLGYSQQPFSKLAPEAGFIDRLNDVYRNFFFTITMDGMGQYQNDFIE-KAVGR------- 237

  Fly   242 TEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGM--------HIYPPKPLPADMQALLD 298
             .:|..|.:.::..|...||:..|..|.||...:|.:||.        |:   .||| |..|.:.
Worm   238 -PLPYWKDLIKEAPVYFTNSNEYLDFAVPTTATIVHIGGFTMDLEKMKHV---DPLP-DKYAKIL 297

  Fly   299 GATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFEDESI---SQLPDNVMVRKWL 359
            ...|..:..|.||.::|..||.......:::|.||.. ..:||:|.:.:   .:||.||.::||:
Worm   298 EERESTVLISFGSVIRSYQMPDNFKAGIIKMFESLPDVTFIWKYERDDVEFQKKLPKNVHLKKWV 362

  Fly   360 PQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISL-HFQSIT 423
            ||..:||...||:|:|||||..|.|..:...|.|.:|.:.||..|.|.....|.|||. .|:...
Worm   363 PQHSLLADNRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPENANMLARHGGAISYDKFELAD 427

  Fly   424 EEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWF 488
            .|.|..::..::.|..|.:|.|.:..:...:|::|:.:.:..:|:.:..........|...:...
Worm   428 GEKLAITIRDMVRNPKYNKNAQELLKVLSHQPIDPKLNLMKHLEFAMEFPNLRSQVPAINQMGLI 492

  Fly   489 QFYLLDVIAFVAIIALAGVMALSLAIRLL 517
            ..|.||||.|:::|.:..|......|.||
Worm   493 AHYYLDVIFFLSLIFILTVYLTFKIISLL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	124/517 (24%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	119/496 (24%)
ugt-8	NP_504315.1	UDPGT	30..516	CDD:278624	122/511 (24%)
ugt-8	NP_504315.1	egt	<284..462	CDD:223071	58/181 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161638
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740