DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt-14

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504316.1	Gene:	ugt-14 / 186767	WormBaseID:	WBGene00019233	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	558	Identity:	140/558 - (25%)
Similarity:	251/558 - (44%)	Gaps:	91/558 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKIL---AVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEK 66
            |::.||.||.:..:       .||   .::||   ||....|.:...:.:.||.||:...:.:..
Worm     6 LVYFLLFTGFISCK-------NILIFNPIFAF---SHVKFVTQMADIIADHGHNVTLFQPYHIAM 60

  Fly    67 EQLGSNYTEILIE----PVYDFW-HDVKLNFGA-----QHLFELTRMTN-----YDFLKMLEIIG 116
            :.     ||.|::    .:.::: ||.....||     ..|::...:.|     |...|.:..:.
Worm    61 KN-----TEGLVKNRKVNIINYYPHDFNTISGAMPETFSGLWDSKLLNNAILSAYAMPKAIGRVF 120

  Fly   117 LKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTL----GYENH 177
            .||....|:...:..    |.|...|:::::|.| :...:.||||.|||.:...:.    .:.|.
Worm   121 EKTATQLLQDESILE----ELKSRKFEVVISEAF-EITEMYLAHLLKIPSIPIKSSVRYPAFNNA 180

  Fly   178 MSQMMGLITPWSFVPHGFMP---FTDRMSFLERVKNSYASFY--EDMDRLLNYFPKMDAVAREFF 237
            ..|...|         |::|   .:..:.||:|:...|..::  :..:||..|  :::.:.:...
Worm   181 FGQPSSL---------GYLPQQGLSREIGFLDRLLEVYDHYFLVKMQERLNEY--QVNFIEKALG 234

  Fly   238 GPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGM-----HIYPPKPLPADMQALL 297
            .|    ||..:.:.::..:.:.||:..|..|.||...:|.|||:     .:..|:.||.:.:.:|
Worm   235 HP----VPHWRDLVKESPIYITNSNPYLDFAVPTTATVVHVGGITMDMKKLKNPQQLPDEYEEIL 295

  Fly   298 DGATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFEDESI---SQLPDNVMVRKW 358
            . ..:..:..|.||.|:|.|||.......:::|.||.. ..:||:|.:.:   .:||.||.::||
Worm   296 Q-ERDSTVLISFGSVVRSCDMPENFKAGVVKMFESLPDITFIWKYEKDDVEFQKKLPKNVHLKKW 359

  Fly   359 LPQADILA-HRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSI 422
            :||..:|| .|.||.|:|||||..|.|..:...|.|.:|.:.||..|.|.....|.||......:
Worm   360 VPQPSLLADKRFVKRFVTHGGLGSTMEVAYTGKPALMVPIFADQFNNANMLARHGGAIPYDKLDL 424

  Fly   423 TE-EILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRS------ 480
            .: |....::.:::.|..|.:|.:.:..|..::|::|:.:.:..:|:.:..   .::||
Worm   425 ADGEKFTKTVREMVINPKYNDNAKVLLIILLNQPIDPKLNLMKHLEFAMEF---PNLRSQIPEIN 486

  Fly   481 -AGLDLNWFQFYLLDVIAFVAIIALAGVMALSLAIRLL 517
             |||    ..:|.||:|||..:.|   .:||.|...|:
Worm   487 NAGL----IGYYYLDIIAFFILFA---CLALYLFTNLI 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	130/526 (25%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	124/502 (25%)
ugt-14	NP_504316.1	egt	5..461	CDD:223071	122/490 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740