DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt-32

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504060.2	Gene:	ugt-32 / 185911	WormBaseID:	WBGene00018543	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	145/565 - (25%)
Similarity:	234/565 - (41%)	Gaps:	81/565 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLE--KE 67
            |||.|::   |||.....:..::|........||......|...|.|:||.||..|....|  |:
Worm     3 LLFKLMI---LYSVFSNTDSLRVLVYSPAYAASHTNFMARLADTLTEAGHNVTFFTPIIDESRKD 64

  Fly    68 QLGSNYT-EILI---------EPV-------YDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEII 115
            |.|...| ::||         .||       | ||           ..::|....:..:..|...
Worm    65 QFGVKLTKDVLILEQDEQVKRNPVTIDNDMKY-FW-----------TTDVTSANGHKVMGTLHKQ 117

  Fly   116 GLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAH--LYKIPVVTTSTLGYENHM 178
            .:.|.|:..   |.:.||. |.:...:|:.|||...........|  :.|: ::|||...|:
Worm   118 AIFTCENVF---KHQELID-ELRSRNYDIGLAEPLMTCGLALFRHIGIEKV-MLTTSCTNYD--- 174

  Fly   179 SQMMGLITP-------WSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREF 236
                 ::.|       .|:.|......||.|||.:|::| |..::..:......|.....|.|::
Worm   175 -----ILLPATGEPEDTSYNPSMNSQVTDVMSFWQRLEN-YDLYHVMIPTFETIFDDEANVYRKY 233

  Fly   237 FGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGG--MHIYPPKPLPADMQALLDG 299
            .|   ...|..:.:....|:...||...|...||::...:.:||  :.|....|:..:...:||.
Worm   234 LG---ESFPDWRDLIPDASLHFTNSIPFLDFPRPSIQKTIEIGGIAVDIESIPPVNEEFSNILDK 295

  Fly   300 ATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFEDESISQLPD--NVMVRKWLPQ 361
            .... :..|.||..:|.:||:......|:||.|... ..:||:|.:.::...|  ||:..||:||
Worm   296 RPMN-MLISFGSLARSTEMPIIFKENLLRVFQSEPNCTFIWKYESDDVAFANDVENVIFVKWMPQ 359

  Fly   362 ADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISL--------H 418
            ..||....:..|:|||||..|.|......|.:..|.:.||..|.|  :||...:|:        :
Worm   360 TAILKDNRLTAFLTHGGLGSTNEAAFLGKPSVMFPIFADQSRNSN--MLGRQEMSIVLHKSDLGN 422

  Fly   419 FQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGL 483
            ||.|     |.:..:::||..|..|.::|:|:.|::|.:||...|..:|:|.|.....||....|
Worm   423 FQKI-----RDAFHEILHNEKYHLNARKVADMVRNQPAKPRDIFVKHVEFVGRFGPLHHMTPYSL 482

  Fly   484 DLNWFQFYLLDVIAFVAIIALAGVMALSLAIRLLMGSNKKHRKAK 528
            .:.::|.|..|:..|..:......:...|.:..|:.|..:.:|.|
Worm   483 KMPFYQRYHYDIFIFKFLTNYFIPVVFLLCVTKLIFSKFQLKKIK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	133/522 (25%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	131/501 (26%)
ugt-32	NP_504060.2	Glycosyltransferase_GTB_type	1..508	CDD:299143	140/544 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161635
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.790