DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt-50

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_741913.1	Gene:	ugt-50 / 181413	WormBaseID:	WBGene00011564	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	127/533 - (23%)
Similarity:	235/533 - (44%)	Gaps:	77/533 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQ-VTMVTAFSLEKEQLGSNYT 74
            ||..|:... :...:|||.......|||.::.:.....|..:||. |..:.::|    :|..||.
Worm    13 LTALLHGSF-IVNAAKILVYCPSISKSHVLLCSKYADLLHNAGHDTVLFIPSYS----KLLDNYD 72

  Fly    75 EILIEPVYDFW--------HDVKLNFGA-----QHLFELTRMT-NYDF-LKM-LEIIGLKTTEHA 123
            ......|   |        :|.||...|     .|:..:.|:| :.|| :.| .:::|
Worm    73 GAKHAKV---WRLHNVTEAYDTKLGTLANVMENSHIGFIDRLTFDADFWIDMCADLLG------- 127

  Fly   124 LRQPKVRSLIHAEQKEGVFDLLLAEQFYQE---AFLALAHLYKIP-VVTTSTLGYENHMSQMMGL 184
             :.|:::.:|..:     |||::    |.|   ...|:..|:.|| .|..|:....:.::..:||
Worm   128 -KLPEMQHIIDYK-----FDLVI----YNEIDPCTPAIVRLFNIPKTVLLSSEAIMDKVAWNLGL 182

  Fly   185 ITPWSFVPH-GFMPFTDRMSFLERVKNSYASF------YEDMDRLLNYFPKMDAVAREFFGPVLT 242
            .|..|:||. ...|..|||||.||:.|.|..|      |.....:||.|.|          .|.:
Worm   183 PTLPSYVPSVEENPNHDRMSFFERMSNVYKFFQSIVVHYLQDIHVLNLFRK----------EVSS 237

  Fly   243 EVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPK--PLPADMQALLDGATEGAI 305
            :.|.:..:.|.:|::|:|:.......|......|.||.:.....:  .||............|::
Worm   238 DFPSIAEIIRNVSLVLVNTDEIFDLPRSYSSKFVYVGMLEAGKDENVTLPKKQDDYFKKGKSGSV 302

  Fly   306 FFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKF------EDESISQL---PDNVMVRKWLPQ 361
            |.|.|:....:.:|.   |:.|.:..::::...:.|      :|||.:|.   ..||.:..|:||
Worm   303 FVSFGTVTPFRSLPE---RIQLSILNAIQKLPDYHFVVKTTADDESSAQFFSTVQNVDLVDWVPQ 364

  Fly   362 ADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEI 426
            ..:|.|.::|:|::|||:....|.::|.|||:.:|.:.||..|.......|....:..:::.:|.
Worm   365 KAVLRHANLKLFVSHGGMNSVLETMYYGVPMVIMPVFTDQFRNGRNVERRGAGKMVLRETVVKET 429

  Fly   427 LRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFY 491
            ...::..::...:|..:|:|:|.:.:::|....:....||::|:::..:.|......:|:..:..
Worm   430 FFDAIHSVLEEKSYSSSVKRISHLMKNKPFTSEERVTKWIDFVLKYETSEHFDLESNNLSIIEHN 494

  Fly   492 LLDVIAFVAIIAL 504
            .||:..::.||:|
Worm   495 HLDLFFYLCIISL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	123/520 (24%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	117/499 (23%)
ugt-50	NP_741913.1	egt	9..475	CDD:223071	120/499 (24%)
ugt-50	NP_741913.1	UDPGT	26..520	CDD:278624	124/519 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810