DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt-18

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_506209.2	Gene:	ugt-18 / 179759	WormBaseID:	WBGene00013900	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	147/571 - (25%)
Similarity:	250/571 - (43%)	Gaps:	88/571 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQFPL-LFGLLLTGTL-YSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFS 63
            |:|.| ||.:|:..|| |         |:|......|.||......:...|:::||.|||:....
Worm     1 MKFALILFFVLIHSTLTY---------KVLVFNPAYGASHSNFLGKISDILIDAGHNVTMLIPEY 56

  Fly    64 L--EKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFE-----------LTRMTNYDFLKMLEII 115
            |  :|:.:||.    .::.|.....|.:    |..|||           :.|| :.:.:.::.|:
Worm    57 LITKKDFVGSK----KVKDVVRIGRDER----AGKLFEEEGIEHMGRARVWRM-DPEMMSLVTIV 112

  Fly   116 GLKT------TEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGY 174
            |...      .|:..:|..:...:..|.    |||.:.|..:...|....|:....|:...:..:
Worm   113 GSMNLAIGYQCEYIFQQKDIIDRLRNEH----FDLAITESLFACPFALFDHIGIKNVINAESNLF 173

  Fly   175 ENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNS---------YASFYE-DMDRLLNYFPKM 229
            ::.:....|.....|:.|..|.|..|:|||:.||||.         |.|.|| :::.:..|:...
Worm   174 KDAVKYAHGEPAAISYYPGLFSPHDDKMSFVARVKNMITMLFTKYLYGSRYEKELEMIKPYYNGT 238

  Fly   230 DAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPK---PLPA 291
            :.....|.|               ::..|:||:..:....|.:...|.||||.:...:   .|..
Worm   239 ETWEDLFTG---------------VAFNLINSNQYIDYPSPALPKTVFVGGMQVNTNEAKTKLSD 288

  Fly   292 DMQALLDGATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFEDES---ISQLPDN 352
            :...:|:...:. :..|.|||..|.:||.|..:.||.|||::.: ..:||:|:.:   .|.|| |
Worm   289 EWNNILNIRKQN-VLISFGSNAFSSEMPEEFKKSFLYVFGNMPEITFIWKYEEANATLTSHLP-N 351

  Fly   353 VMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISL 417
            |.:..|:||.|:||...:.:|:|||||..|.|..:...|.|.||...||..|.:.....|..:..
Worm   352 VKLTTWMPQNDLLADDRLTLFVTHGGLGSTMELAYQGKPALIIPLMADQPRNAHMLKRHGGCLQY 416

  Fly   418 HFQSI--TEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRS 480
            |...:  :|::|: :...::....|.||.||::.|.||:|:.|:...:...|:.:.|...:.:.|
Worm   417 HKTMLGDSEQLLK-AFKTVLTERKYSENAQRLARILRDQPVSPKDLVLKHCEFAVEHGALNSLNS 480

  Fly   481 AGLDLNWFQFYLLDVIAFVAIIALAGVMAL--------SLAIRLLMGSNKK 523
            .|..||.||||..|:.:.:.::||..::.:        .|..|:.:....|
Worm   481 RGRYLNTFQFYSFDIASSIVMLALLVLVFIYFTLLFIFKLVARIFLSQKTK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	133/519 (26%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	130/498 (26%)
ugt-18	NP_506209.2	UDPGT	19..512	CDD:278624	135/523 (26%)
ugt-18	NP_506209.2	Glycosyltransferase_GTB_type	<252..504	CDD:299143	78/254 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161617
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790