DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt-6

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001369960.1	Gene:	ugt-6 / 179755	WormBaseID:	WBGene00013904	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	142/569 - (24%)
Similarity:	234/569 - (41%)	Gaps:	102/569 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLG 70
            ||...|.|..||.       |.|.:....|.||......|...|..:|:.||....|.:::....
Worm     8 LFISTLFGNAYSY-------KFLVISPVYGFSHMKYMAELANHLARAGNDVTYFQPFVVDEYHDH 65

  Fly    71 SNYTEILIEPVYDFWHDVKLNFGAQHL-------------------FELTRMTNYDFLKMLEIIG 116
            :...|..|: :::::||   ..|.||:                   .....::.|.|
Worm    66 TLIKEKSIK-IWNYYHD---ELGRQHIPSQGCMRDAWHSSWYQSDAGAAILLSKYLF-------- 118

  Fly   117 LKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIP-VVTTSTLGYENHMSQ 180
             ...||..|:....:.:|.:.|...||::|:|.| ....|.||...::| :::|.|....|.::.
Worm   119 -PAFEHMCRKMFEDTELHYDLKSRQFDVVLSEAF-DFCGLYLASYLEMPSIISTFTGNRLNALAP 181

  Fly   181 MMG-------LITPWSFVPHGFMPFTDRMSFL-ERVKNSYA------SFYEDMDRLLNYFPKMDA 231
            ::|       |..|.|...|....| ||::.: .::.:||.      ..|:.:.:|.|
Worm   182 VLGEPSFLHYLPAPTSQYGHESTIF-DRLNDVWHKIWSSYGFAQLFEMQYQQVSKLTN------- 238

  Fly   232 VAREFFGPVLTEVPKVKHME---RQISVMLLNSHAPLTTARPTVDAMVPVGGM---HIYPPKPLP 290
                         .||||.:   ..::....||:..|....||:..:||:||:   |.|  ....
Worm   239 -------------GKVKHWKDIIHDVTYHFSNSNPYLDFVIPTIPKVVPIGGITVDHDY--WSTN 288

  Fly   291 ADMQALLD---GATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFE----DESIS 347
            .:...||:   .|.:..:|.|.||.|:|.|||.|..:..::||..... ..|||:|    .|.:.
Worm   289 GNHSELLEHVLNARKHNVFISFGSMVRSVDMPKEFKKSMMKVFSDHPNITFLWKYELPNDQEFLR 353

  Fly   348 QLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVL-G 411
            .||.||.|.||..|:.:|:.:.|.:|:|||||..|.|....|.|.:.||.:.||..|...... |
Worm   354 ILPTNVHVAKWFSQSALLSDQRVNLFVTHGGLGSTMELARAAKPAIVIPLFADQPGNAKMIERHG 418

  Fly   412 GYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGAS 476
            ...|.........:.|...:.::::...|::|..|::|..|.:|:.|....|...|...|.....
Worm   419 SVEIFSKLDIPNSKKLSSLIQKMLNTKYYQQNANRLADTLRFQPITPTDLMVKHAENAARFGKMP 483

  Fly   477 HMRSAGLDLNWFQFYLLDV--IAFVAIIALAGVMA-------LSLAIRL 516
            ::.....|:.:|::|.:|:  |.|:.:..|..|:|       |||.|::
Worm   484 NLVPHAKDMGFFEYYNIDIIFIVFLLVWLLFSVVAHVFSKLKLSLKIKV 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	129/532 (24%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	125/511 (24%)
ugt-6	NP_001369960.1	GT1_Gtf-like	20..456	CDD:340817	116/479 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810