DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt-5

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_506200.1	Gene:	ugt-5 / 179753	WormBaseID:	WBGene00013906	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	142/571 - (24%)
Similarity:	236/571 - (41%)	Gaps:	93/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLE--KE 67
            |:|.||....:.|...|.    |..||.|   ||......:..:|.::|||||....|.:|  |:
Worm     8 LIFVLLFIKNVASYNFLV----ISPVYGF---SHMKSMAIIANQLADAGHQVTYFQPFVVELFKD 65

  Fly    68 QLGSNYTEILIEP---VYDFWHDV--KLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTE----HA 123
            .      :::..|   :.:::||.  |.|... |.......|:|   |....:|.|...    |.
Worm    66 H------DLIKNPNIEIMNYFHDEEGKKNIPG-HSVLSDAWTSY---KYQSDVGQKIFAPRILHQ 120

  Fly   124 LRQPKVRSL-----IHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYE-NHMSQMM 182
            ..|...|.:     :|.:.|:..||::|:|.| ....|.||...::|.:.:...|.. |.::..:
Worm   121 SFQEMCRHMFEDEALHRQLKDKKFDVVLSETF-DFCGLYLADYLEMPAIISVFTGNRLNAITNAL 184

  Fly   183 GLITPWSFVPHGFMPFTDRMSFLERVKN------SYASF-------YEDMDRLLNYFPKMDAVAR 234
            |..:...::|.....|...||..:|..|      |.::|       |.|:.||.|      ..||
Worm   185 GEPSFLHYLPSPSSSFNANMSLYDRFNNFWHKILSSSTFGELFDRQYADVYRLTN------GKAR 243

  Fly   235 EFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGG--MHIYPPKPLPADMQALL 297
            .:           |.:...::....||:..|....||:..::|:||  |......|:..|:..:|
Worm   244 HW-----------KQILNDVTYHFSNSNPYLDFVIPTIAKVIPIGGYTMDYKQVPPVSKDLDTIL 297

  Fly   298 DGATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFEDES----ISQLPDNVMVRK 357
            : .....:|.|.|:.:.:|.||.|..:..:..|...|. ..|||:|:..    ...:||||.:..
Worm   298 N-LRSSTVFISYGTMISAKYMPDEYKQSMIDFFKDNKNVTFLWKYEEPEEKFIKENIPDNVHLST 361

  Fly   358 WLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSI 422
            |.||..:||.:.||:|||||||..|.|..:.|.|.:..|.:.||..|         |..|.....
Worm   362 WFPQQSLLADKRVKLFITHGGLGSTMELAYSAKPAIVTPLFADQPSN---------AQMLERHGS 417

  Fly   423 TEEILRHS----------LDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASH 477
            .|.:.:|.          |..::.:..|:|...|::||..::|:.||:..:...|...|......
Worm   418 VEVLSKHDIPNWKKQSDLLKTMLADKKYQEAATRLADILNNQPISPRELMLKHAENAARFGKIPS 482

  Fly   478 MRSAGLDLNWFQFYLLDVIAFVAIIALAGVMALSLAIRLLMGSNKKHRKAK 528
            :.....|:.:.:||.:|:|.:.....|..:. :::.|..::.:..|.||.|
Worm   483 LTPFAKDMGFIEFYNIDLIIYSVSFTLFAIY-VTIEIFGIVKNCCKTRKLK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	130/528 (25%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	126/507 (25%)
ugt-5	NP_506200.1	egt	6..509	CDD:223071	136/545 (25%)
ugt-5	NP_506200.1	UDPGT	32..527	CDD:278624	129/536 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740