DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt-49

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_505666.2	Gene:	ugt-49 / 179446	WormBaseID:	WBGene00007070	Length:	525	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	147/573 - (25%)
Similarity:	239/573 - (41%)	Gaps:	95/573 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FPLLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTM-VTAFSLEK 66
            :..||.||       .|...:..|||.......:||.:.:..:...||::||.|.| :|.:....
Worm     2 YTFLFLLL-------SLLAVDAGKILVYSPSISRSHLISNGRIADALVDAGHDVVMFITEYEPLT 59

  Fly    67 EQLGSNYTEILIEPVYD--FWHDV-----------KLNFGAQHLFELTRMTNYDFLKMLEIIGLK 118
            |..|:...:::....:.  |..|:           :|:|..:.:||.|.....|        .|.
Worm    60 EFTGTKKAKVITMKGFSTKFAEDMDGIGEYLLSSSRLSFLERLMFEKTCTGACD--------DLM 116

  Fly   119 TTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHM----- 178
            |....|.|.:..:          ||:..:||.         .|..:.:|  ..||.:||:
Worm   117 TRREELEQLRAYN----------FDVAFSEQI---------DLCGVGIV--RYLGIKNHLWISTT 160

  Fly   179 ------SQMMGLITPWSFVP------HGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDA 231
                  |..:|:..|.|:||      :|     |:|.|.:|..|    .|..:..:|.:....|.
Worm   161 PIMDAVSYNLGIPAPSSYVPTIEENDNG-----DKMDFWQRTFN----LYMKIGSILIHRYGTDG 216

  Fly   232 VAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYP--PKPLPADMQ 294
            .. |.|...:.:.|.|:.:....|:..:||...|...|||:...:.|||:.| |  .|||.....
Worm   217 TT-EVFRKYIPDFPNVREIAANSSLCFVNSDEVLDLPRPTITKAIYVGGLGI-PKVSKPLDKKFT 279

  Fly   295 ALLDGATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFE--DESISQLPD---NV 353
            .::....||.:..||||.:...|:|.......|:....:.. ..|.|..  |.:..:|.:   ||
Worm   280 NIMSKGKEGVVIISLGSIIPFGDLPAAAKEGVLRAIQEISDYHFLIKIAKGDNNTKKLVEGIKNV 344

  Fly   354 MVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLN---MNKAVLGGYAI 415
            .|.:||||.|||:|..:|:|:.|||:.|..|....|||.:.:|.:.||..|   :.|..:|...:
Worm   345 DVAEWLPQVDILSHPRLKLFVMHGGINGLVETAIQAVPTVIVPVFADQFRNGRMVEKRGIGKVLL 409

  Fly   416 SLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRS 480
            .|   .|..|..::::..:::..:||:|..|:..:.||:|..|.:....|.::.|.|.....:..
Worm   410 KL---DIGYESFKNTVLTVLNTPSYKKNAIRIGKMMRDKPFSPEERLTKWTQFAIDHGVLEELHV 471

  Fly   481 AGLDLNWFQFYLLDVIAFVAIIALAGVMALSLAIRLL---MGSNKKHRKAKQN 530
            .|..||...:|.|||||||..:.:|.:.....|.:.|   ..|....:|:|:|
Worm   472 EGSRLNTIIYYNLDVIAFVLFVFVAVLHVFIYAFKFLCCKKRSQSNIKKSKKN 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	135/523 (26%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	129/502 (26%)
ugt-49	NP_505666.2	UDPGT	17..523	CDD:278624	140/548 (26%)
ugt-49	NP_505666.2	egt	<162..464	CDD:223071	87/315 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14680
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710