DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt-29

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001370778.1	Gene:	ugt-29 / 178581	WormBaseID:	WBGene00021709	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	130/552 - (23%)
Similarity:	235/552 - (42%)	Gaps:	46/552 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTGTLYSQLELAEGSKILAVYAFP--GKSHFMMHTALIRELVESGHQVTMVTAF---SLEKEQ 68
            :||...:::.|..:..|..:.||: |  ..||......|...|.|.||.||.:...   ....|.
Worm     1 MLLNSLIFTLLFCSSSSLNILVYS-PAYAASHSNFLGKLADTLTERGHNVTYLMPVMDPGKRDEC 64

  Fly    69 LGSNYTEILI-----EPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPK 128
            :|...|:.|:     |.:......|.|:.....|:..:.|.:.:...|..... ...:.|.|...
Worm    65 IGVKLTKDLVIVEADEEMMSREEGVTLDEEIMELYWKSEMDSSNSRDMFSFFN-NAMKAACRNFL 128

  Fly   129 VRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPV---VTTSTLGYENHMSQMMGLITPWSF 190
            .|..|..:.|...||:.:.|..   :...|..:..:.:   :..|:..:.:.:...:|....:|:
Worm   129 KRRDIFEQMKSRNFDVAIVEPL---SVCGLGFVKALGIEKTILASSCTFYDSIMDYIGEPLDFSY 190

  Fly   191 VPHGFMPFTDRMSFLERVKNSYAS------FYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKH 249
            ||..|....|.|:..||.:|...:      .:|..|..:..:       |||.|   .::|..:.
Worm   191 VPALFSVTGDVMTMSERYENWMVTKEINIGIHEKFDDEMKSY-------REFLG---QDLPDWRE 245

  Fly   250 MERQISVMLLNSHAPLTTARPTVDAMVPVGGMHI----YPPKPLPADMQALLDGATEGAIFFSLG 310
            :....|:..:||:......||.:...||:||:.:    ...:.|..|.:.:|: ..:..:..|.|
Worm   246 LLSTASIFFINSNPFFDFPRPVLQKTVPIGGISVNLKWIKEQKLTKDWEEVLE-MRKKTVLISFG 309

  Fly   311 SNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFE--DESISQLPDNVMVRKWLPQADILAHRHVKV 372
            |.|:|..||.:.....|.|..|:.. ..:||:|  |.|.:....|:...||:||..:|....:.|
Worm   310 SLVKSAYMPKKWRNGLLDVIKSMPDVTFIWKYETDDVSFADGVSNIHFSKWVPQTALLNDPRLSV 374

  Fly   373 FITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITE-EILRHSLDQLIH 436
            |:|||||..|.|..:...|.:.||.:.||..|.|........|.||..|:.. ::.|.:...::.
Worm   375 FVTHGGLGSTMELAYSGKPAVVIPVFADQIRNANMIARHRGVIYLHKNSMENVKVTRKAFTDVLF 439

  Fly   437 NVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAI 501
            :.:|::|.:::::|..::|..|:::.:.:.|::..|....:|...|..||:||...||:....|:
Worm   440 DDSYQKNAEKLANILMNQPYSPKENVIKYTEFLGEHGPFPNMDPHGRHLNYFQKTFLDIYTLFAL 504

  Fly   502 IALAGVMALSLAIRLLMGSNKKH---RKAKQN 530
            ..:.....:.:.||.:....:||   .|:|:|
Worm   505 FYIFVSTIIIVTIRFVYKFTRKHFILVKSKEN 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	120/508 (24%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	115/485 (24%)
ugt-29	NP_001370778.1	GT1_Gtf-like	18..468	CDD:340817	108/465 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161578
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.790