DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt-22

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_502633.1	Gene:	ugt-22 / 178330	WormBaseID:	WBGene00007455	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	147/551 - (26%)
Similarity:	244/551 - (44%)	Gaps:	68/551 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTM---VTAFSLE-KEQL 69
            |||.|   |.:.|.|..|||......|.||..|..|:...|.::||.:|:   |..|..| |..:
Worm    11 LLLLG---SFVGLTEPYKILMYTNLFGHSHIKMLGAVSDTLTDAGHDLTVLMPVIDFKQENKTAM 72

  Fly    70 GSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIH 134
            .|....|.|:|    ..|:.........| :|::...|....|.::.......|:...:.|.::
Worm    73 KSTKNIIKIQP----GQDISKTIETMEKF-MTQLWTTDNSNPLFMVFHAPAMSAIFASQCRKVL- 131

  Fly   135 AEQKEGV-------FDLLLAEQF----YQ--EAFLALAHLYKIPVVTTSTLGYENHMSQMMGLIT 186
             |.||.:       |||.:.|.|    |.  ||....||   :.|::.|.|   :|:|:.:|...
Worm   132 -EDKELIERLRAENFDLAITEPFDTCAYALFEAIKIRAH---VAVLSCSRL---DHVSKAIGQPI 189

  Fly   187 PWSFVP-----HGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMD-AVAREFFGPVLTEVP 245
            ..|:||     ||     :||:..:|..|.......|.  |.:|....| .||:|.       :|
Worm   190 APSYVPGTQSTHG-----ERMTIWQRFMNILHFLMGDF--LFSYIGDEDFKVAKEI-------IP 240

  Fly   246 KVKHMERQI--SVMLLNSHAPLTT-ARPTVDAMVPVGGMHIYPPK---PLPADMQALLDGATEGA 304
            .|:.....:  :..:..:|.||.. ..||.|.::|:||:.:...|   .||.....:| |..:..
Worm   241 GVRSWREVLPEASFIFTNHIPLMDFPAPTFDKIIPIGGISVKTQKKSLELPEKWNKIL-GLRKKN 304

  Fly   305 IFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFEDE--SISQLPDNVMVRKWLPQADILA 366
            |..|.|||.:|.|||....:..|:|..|:.. ..:||:|:|  :::...|||.:..||||.::|.
Worm   305 ILVSFGSNARSADMPEHFKQNVLKVAESMPDVTFIWKYENEKDTLADHLDNVYLGDWLPQNELLG 369

  Fly   367 HRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSI-TEEILRHS 430
            ...:.:|:|||||....|......|.:.:|.:.||..|.|.....|.|..||...: ..|.:|::
Worm   370 DPRLSLFVTHGGLASVTELALMGKPAVMVPLFADQARNANMLKRHGGAAVLHKTDLGNAETIRNT 434

  Fly   431 LDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDV 495
            :.:::.|..|:.|.:|::::..::|..|:.:.:..:|:..:......|...|...::.::||||:
Worm   435 IKKVLENEKYRVNAERLAEMLNNQPTNPKDTLIKHVEFAAKFGQLPSMDPYGRHQSYIEYYLLDI 499

  Fly   496 IAFVAIIALA----GVMALSLAIRLLMGSNK 522
            |:...::.|.    ....:....|:..||.|
Worm   500 ISIALVLILTTSFISFQLIKCTFRMCCGSGK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	136/514 (26%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	131/493 (27%)
ugt-22	NP_502633.1	UDPGT	36..530	CDD:278624	135/521 (26%)
ugt-22	NP_502633.1	egt	<256..515	CDD:223071	72/259 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161569
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14115
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790