DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt-44

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_501933.1	Gene:	ugt-44 / 177939	WormBaseID:	WBGene00008486	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	121/542 - (22%)
Similarity:	236/542 - (43%)	Gaps:	54/542 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FGLLLTGTLYSQL--ELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLE---- 65
            :.|||....|||.  .:....|:|......|.||......:...|.:.|:.||::.....|
Worm     6 YALLLIIVYYSQTINGIERPKKVLVFMPISGHSHLKFMGTIANILQDEGYNVTLLLPILDEGLRD 70

  Fly    66 --------KEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEH 122
                    |.::....:|.|||        ....|.|....|.|.:.|...:..|: :|.|...
Worm    71 TTPLVRKIKNRILVEQSEELIE--------ANAQFRAGGGRENTWVMNSGIIGFLK-LGTKVAN- 125

  Fly   123 ALRQPKVRSLIHAEQ-----KEGVFDLLLAEQFYQEAFLALAHL-YKIPVVTTSTLGYENHMSQM 181
             :.:...:::...|.     ::..||:.::|..|...|....|| .:..:.|.|.||.|  :|::
Worm   126 -ICKASCKNVFQNEDLINYLRDQRFDVAISEPLYTCGFALFDHLGIETTISTDSHLGLE--VSKI 187

  Fly   182 M-GLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFG--PVLTE 243
            . |.....|::|..|...::||:.:.|.||...|::       ||:........|..|  .:...
Worm   188 AHGASISTSYLPAVFSSGSERMTLIGRAKNYVESYF-------NYYFNSKIYENELAGIEGIYKN 245

  Fly   244 VPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKP--LPADMQALLDGATEGAIF 306
            ....:.:.|:.:.|.:||:..:....|.....:.:||:...|.|.  ||.:...:| ...:..:.
Worm   246 GKGWRELSRKNAYMFVNSNPQMDIPSPRTSKFIEIGGISSGPVKQERLPEEYDRVL-SLRKKNVL 309

  Fly   307 FSLGSNVQSKDMPVEMLRLFLQVFGSLKQRV-LWKFEDESI------SQLPDNVMVRKWLPQADI 364
            .|.|:|.:|..|..:|....::.|.|:.... :||:|:.::      ::..:|||:..|:||..:
Worm   310 ISFGTNAKSMFMSDDMKESLIKTFESMPDTTFIWKYENTTVDIVKQYNKRINNVMLTDWMPQTAL 374

  Fly   365 LAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITE-EILR 428
            ||...:.:|:|||||..|.|......|.:.:|.:.||..|.........|:.|....:|. :.:|
Worm   375 LADPRLTLFVTHGGLGSTNEVAFSGKPSIMVPVFGDQTRNARMLERHEVALVLTKYDLTNFKKVR 439

  Fly   429 HSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLL 493
            .::.:::::.:|....::::.:.|::|..|::..:.:..:|.|......:.|...::::.:||.:
Worm   440 GTIRKMLNDKSYSMKAEKLAQMLRNQPESPKEIFIKYFNFVARFGKPHGLDSYAAEMSFIEFYYI 504

  Fly   494 DVIAFVAIIALAGVMALSLAIR 515
            |.:|.::|.::|..|.:|..:|
Worm   505 DFMAILSIFSVALYMIVSKVLR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	111/512 (22%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	106/491 (22%)
ugt-44	NP_501933.1	UDPGT	27..510	CDD:278624	110/503 (22%)
ugt-44	NP_501933.1	egt	<250..519	CDD:223071	61/269 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161593
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790