DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt-45

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_500410.2	Gene:	ugt-45 / 177139	WormBaseID:	WBGene00021372	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	125/535 - (23%)
Similarity:	235/535 - (43%)	Gaps:	45/535 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQL 69
            |:|.||..      |..|...|||......|.||......|...|||:||.||.:....:...|.
Worm     4 LVFLLLFV------LPAASCYKILVSVPKFGFSHMQTMGKLADILVEAGHDVTFLMPVDVPIPQN 62

  Fly    70 GSNYTEILIEPVYDFWHDV---KLNFGA-QHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVR 130
            |:...::::.|..|..:::   .:..|| .:|:..:..:....:...::|| :.:.|..:.....
Worm    63 GTELAKVVLVPTTDAINEIMGHAMKSGAVANLWTHSANSKQGIMWSTDMIG-QVSYHNTKNLIDN 126

  Fly   131 SLIHAEQKEGVFDLLLAE--QFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPH 193
            ..:..:.|:..||:.:.|  .|...||..:..|..:....|::: :|..:......|.| ||||
Worm   127 KALVQQMKDEKFDIGITELFDFSGLAFFEVIGLKNVMGAHTTSV-FEGTLMATGAPILP-SFVP- 188

  Fly   194 GFMPFTDRM-SFLERVKNSYASF--YEDMDRLLNYFPKMDAVAREFFGPVLTE------VPKVKH 249
            ....|||.. |.|.|:.|.|.::  |:..:::.::..|           .|.|      .||:.:
Worm   189 ASQTFTDDSGSILSRLNNLYMTYWSYQFQNKIQSFAQK-----------ALDEHYEKGKAPKIWN 242

  Fly   250 MERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATEGAIFFSLGSNVQ 314
            :...|:...:||.......:|....:|.:.|:.:...||:..:...:|...::. :..|.||...
Worm   243 LVSDITWFFVNSDPIFDFPKPLPQNIVEIAGISVPEIKPVGKEWDEILSKRSKN-VLVSFGSIAS 306

  Fly   315 SKDMPVEMLRLFLQVFGSLKQ-RVLWKFEDESISQLP---DNVMVRKWLPQADILAHRHVKVFIT 375
            ...||..:.:..:..|.:... ..:||::|.. |:|.   |||.:.||:||.|:||.:.:.:|.|
Worm   307 PTTMPEAVKKSIVDAFAAFPDVTFIWKYDDTE-SKLTAHLDNVHIVKWMPQNDLLADKRISMFWT 370

  Fly   376 HGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSI--TEEILRHSLDQLIHNV 438
            |||:....|....:||::.:|.:.||..|...|...|.|:......:  |:::: .:|.:::.|.
Worm   371 HGGMGSLMESAQKSVPLVVVPIFGDQMRNAQIAKRHGVALIYDKMDLSNTKKLI-GALKEVLENP 434

  Fly   439 TYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIA 503
            .||::.:.::.|.......||:..:..:|...|........|||.:.::.:::.||::.....|.
Worm   435 EYKKSAELLARILATERFSPRQKIIDTVEMAGRFGQMPRWTSAGKEFSFLKYFNLDLVIIAVFIF 499

  Fly   504 LAGVMALSLAIRLLM 518
            ...:::..|.||.|:
Worm   500 FLSIVSTVLLIRHLL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	116/502 (23%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	110/481 (23%)
ugt-45	NP_500410.2	egt	14..513	CDD:223071	119/516 (23%)
ugt-45	NP_500410.2	UDPGT	19..510	CDD:278624	116/508 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14613
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860