DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt-62

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_497918.1	Gene:	ugt-62 / 175591	WormBaseID:	WBGene00010904	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	138/544 - (25%)
Similarity:	235/544 - (43%)	Gaps:	86/544 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQFPLLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMV------ 59
            |:...|| |||.|.:       ...|......:...|.....|.:...|...||.|||:
Worm     1 MKLIALF-LLLLGAV-------SAYKYAVFVPYMANSQVQFCTRVAEVLANGGHDVTMIHLSHLP 57

  Fly    60 ------------------------TAFSLEKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFE- 99
                                    |...|||||....:.:..::.: .....:...||  .:|:
Worm    58 DYKTDVKIPKNIKVHRVEAYVEGLTKALLEKEQSAFIFKDTGLKDM-PAMMSMFSRFG--KMFQD 119

  Fly   100 ----LTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAH 160
                :.|  |.:|:|.||                      .:|   ||:..: ..|....:.|.|
Worm   120 GCRNIVR--NKEFMKWLE----------------------NEK---FDVAYS-YIYSSCPIGLIH 156

  Fly   161 LYKIPV-VTTSTLGYENHMSQMMGL-ITPWSFVPHGFMPFTDRMSFLERVKNSYA-SFYEDMDRL 222
            ..|||. |..::....:.:::.:|: |.| |:||...|...|.|.|..|:|:... :....:.|.
Worm   157 AAKIPSWVWLNSGALMDFVAETVGVPIIP-SYVPPLMMESDDEMGFFFRMKSFIGHTLMTVLHRR 220

  Fly   223 LNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHI--YP 285
            :....:......|...|   ..|....:..:..::::||:......|||:..:|.:||:.:  ..
Worm   221 MTSNGETQIFRDELNDP---NFPHTMDLGAKCPLVIVNSNELYDLPRPTLAKVVNIGGLGVGFDS 282

  Fly   286 PKPLPADMQALLDGATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLK--QRVLWKFEDESISQ 348
            .|||..:.:.:.: ..:|.|.||.||...:.|||:|.....|:.|.||.  |.::....|:...:
Worm   283 AKPLTGEFKKISE-TGKGMIVFSFGSVAAAHDMPLEWKNSILEAFSSLPDYQFLMRYVADDLNDR 346

  Fly   349 LPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGY 413
            ||.||.:.|||||.|:|.|...|.||||||....||.:...||::.|..:.||..|...|...|:
Worm   347 LPKNVHLFKWLPQKDLLLHNKTKAFITHGGYNSMQEAISAGVPLVTIALFGDQPKNSKVAKKHGF 411

  Fly   414 AISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHM 478
            |:::....|:::.:..::.:::.|.:||:.|.|:|.:.|.:|::|.:..:.|.|::...:...::
Worm   412 AVNIQKGEISKKTIVKAIMEIVENDSYKQKVSRLSAMVRAQPMKPAERLLKWSEFLAEFKTLDNL 476

  Fly   479 RSAGLDLNWFQFYLLDVIAFVAII 502
            ..||..||:||::.||||.|:.|:
Worm   477 EPAGQKLNFFQYHSLDVITFLFIV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	131/523 (25%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	128/502 (25%)
ugt-62	NP_497918.1	UDPGT	37..520	CDD:278624	128/500 (26%)
ugt-62	NP_497918.1	egt	<251..471	CDD:223071	69/220 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161527
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14329
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740